PMID: 9194131Jun 1, 1997Paper

The feasibility of measuring bone uranium concentrations in vivo using source excited K x-ray fluorescence

Physics in Medicine and Biology
J M O'MearaC E Webber

Abstract

X-ray fluorescence (XRF) has been demonstrated to be an extremely useful technique for measuring trace quantities of heavy metals in various tissues within the body. This study investigates the applicability of XRF to the measurement of bone uranium concentration. The factors affecting the accuracy and minimal detectable concentration of bone uranium in vivo are discussed. The system chosen employs a 57Co source to excite the uranium K x-rays, with the source and detector in an approximate 180 degrees backscatter geometry relative to the sample position. It is demonstrated, with experiment and Monte Carlo simulation, that the x-ray to coherent peak ratio is linearly related to concentration and is independent of variations in source-sample geometry, thickness of overlying tissue and tibia size. Preliminary in vivo measurements indicate that this system has a minimum detectable concentration of approximately 20 micrograms U/g bone mineral which may not be sufficiently precise for a monitoring system for occupational workers. Future work will involve attempts to enhance this precision through the use of alternative sources for the excitation of uranium x-rays as well as possible modifications to the detector and electronics.

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Citations

Feb 13, 2001·Computers in Biology and Medicine·F H Al-GhorabieS H Al-Lyhiani
Apr 9, 2004·Medical Physics·A Pejović-MilićD R Chettle
Aug 21, 2001·The British Journal of Radiology·R F Mould
Sep 24, 2004·Physics in Medicine and Biology·S A Graham, J M O'Meara
Jun 23, 2006·Physics in Medicine and Biology·Sören Mattsson, Brian J Thomas
Oct 19, 2006·Physics in Medicine and Biology·Ryan C N StudinskiDavid R Chettle
Apr 4, 2007·Physics in Medicine and Biology·M ZamburliniJ Gyorffy
Jul 19, 2008·Physics in Medicine and Biology·M ZamburliniD R Chettle
Jul 29, 2017·Physiological Measurement·Joanna NguyenJames L Gräfe
Dec 10, 2019·Physiological Measurement·David R Chettle, Fiona E McNeill
Jul 3, 1998·Physics in Medicine and Biology·J M O'MearaC E Svensson
May 12, 2020·Physiological Measurement·Joanna NguyenJames L Gräfe
Aug 24, 2017·Physiological Measurement·Z KeldaniJ L Gräfe
Mar 19, 2005·Physics in Medicine and Biology·Ryan C N StudinskiJoanne M O'Meara
May 21, 2020·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Yukie IzumotoHiroshi Yoshii
Jun 29, 1999·Analytical Chemistry·W M DraperP R Michael

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