The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval

Anesthesia and Analgesia
John DingleyMarianne Thoresen

Abstract

Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early. During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system. Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL). Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.

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Jul 29, 2005·Annals of Neurology·Daqing MaMervyn Maze
Dec 24, 2005·Stroke; a Journal of Cerebral Circulation·John DingleyMarianne Thoresen
Jan 15, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marianne ThoresenJohn Dingley
Jul 27, 2010·Annals of Neurology·Elavazhagan ChakkarapaniMarianne Thoresen
Apr 18, 2013·Anesthesiology·Hemmen SabirMarianne Thoresen

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Citations

Jul 23, 2016·Therapeutic Hypothermia and Temperature Management·Patrick KochanekMarianne Thoresen
Nov 8, 2017·Paediatric Anaesthesia·Hannah Gill
May 17, 2018·Frontiers in Neurology·Hemmen SabirMarianne Thoresen
Jun 26, 2020·Frontiers in Cellular Neuroscience·Juan Carlos FernándezAlfredo Martínez
Feb 26, 2020·Intensive Care Medicine Experimental·Roehl AnnaCoburn Mark

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