The feasibility of using actigraphy to characterize sleep in Rett syndrome

Journal of Neurodevelopmental Disorders
Alyssa M MerblerFrank J Symons

Abstract

Rett syndrome (RTT) is a neurodevelopmental disorder primarily caused by mutations in the MECP2 gene. Sleep problems are reported by the majority of caregivers of individuals with RTT. The present study aimed to replicate and extend previous work about the feasibility of measuring sleep with an actigraph device in a sample of girls with clinically diagnosed RTT (N = 13, mean age = 9 years, 5 months). Participants wore an actigraph device day and night for seven consecutive days. Materials also included a parent-completed sleep diary to measure bedtime, duration of nighttime sleep, and daytime sleep, and the Child Sleep Habit's Questionnaire (CSHQ). The means for the sample as measured by actigraphy were 492.3 min (SD = 47.3) of total night sleep (TNS), 76.0% (SD = 6.7) sleep efficiency, 86.0 min (SD = 34.2) of wake after sleep onset, and 46.1 min (50.8) of sleep when parents reported a nap occurring. Parents reported 589.7 min (SD = 53.6) of TNS, 15.9 min (SD = 12.0) of WASO, and 93.6 min (SD = 66.8) of daytime sleep according to sleep diaries, with all parents reporting at least one nap during the week. Relations were found between sleep characteristics and seizure status and CSHQ total scores. No age-related changes were obse...Continue Reading

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Citations

Aug 5, 2020·FEBS Letters·Anna-Marie FingerAchim Kramer
Jul 24, 2020·Journal of Neurodevelopmental Disorders·Sarika U PetersDouglas A Granger
Oct 27, 2021·American Journal on Intellectual and Developmental Disabilities·Jamie BarsteinCharlotte Distefano

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Software Mentioned

Phillips Actiwatch
actigraphy

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