Abstract
To investigate the relationship between microRNA107 (miRNA107) and BACE1 messenger RNA (mRNA) gene expressions in plasma and their diagnostic capability to distinguish subjects with amnestic mild cognitive impairment from healthy controls. We recruited 97 patients with Alzheimer's disease according to diagnostic criteria of DSM-IV and National Institute of Neurologic and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association, 116 subjects with amnestic mild cognitive impairment, and 81 healthy controls from January 2012 to December 2012. The real-time PCR was used to quantify miRNA107 and BACE1 mRNA. The power of classification accuracies between patients with amnestic mild cognitive impairment and healthy controls was performed using linear discriminate analysis single or combining both the expression miRNA107 and BACE1 mRNA. For patients with Alzheimer's disease, the miRNA107 expressions in plasma and cerebral spinal fluid were correlated (Pearson correlation = 0.665, P = .034). There were statistically significant correlations between plasma miRNA107 and BACE1 mRNA gene expression in Alzheimer's disease, amnestic mild cognitive impairment, and healthy control groups (r value = -0.316 [P = .0...Continue Reading
Citations
Mar 17, 2016·Translational Neurodegeneration·Sofie Sølvsten SørensenThomas Christensen
Mar 23, 2017·Progress in Neurobiology·Mark J Millan
Oct 21, 2015·Journal of Alzheimer's Disease : JAD·Helen Zong Ying WuKaren Mather
Oct 6, 2019·Neuromolecular Medicine·J Weldon FurrLouise D McCullough
Oct 2, 2015·PloS One·Giovanni LugliNeil R Smalheiser
Oct 28, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Mehmet Akif CamkurtEbru Fındıklı
Apr 11, 2019·International Journal of Molecular Sciences·Seongju LeeJu-Hee Kang
Dec 25, 2019·Scientific Reports·Jessy A SlotaStephanie A Booth
Jun 27, 2019·Molecular Neurobiology·Soraya Herrera-EspejoÁfrica Garcia-Orad
Sep 26, 2020·Frontiers in Molecular Neuroscience·Wei WeiHao Li
Sep 24, 2016·Journal of Alzheimer's Disease : JAD·Bing XieShunjiang Xu
Feb 9, 2019·Molecular Neurobiology·S SwarbrickAlexandra Stolzing
Aug 9, 2017·Frontiers in Aging Neuroscience·Yimeng ChenShengdi Chen
Oct 24, 2020·American Journal of Alzheimer's Disease and Other Dementias·Dan ShiLidian Chen
Feb 6, 2021·The International Journal of Neuroscience·Hongyun QinBinggen Zhu
Dec 10, 2019·Progress in Neurobiology·M M J van den BergJ J Briedé
Dec 15, 2020·Oxidative Medicine and Cellular Longevity·Akihiko Nunomura, George Perry
Feb 13, 2021·Biomolecules·Matea Nikolac PerkovicNela Pivac
Jun 1, 2021·Neural Plasticity·Miao HeShu-Guang Gao
Jul 11, 2021·Alzheimer's Research & Therapy·Sze Chung YuenSiu-Wai Leung
Aug 10, 2021·Journal of Alzheimer's Disease : JAD·Haining HeTao Wang