The features of cerebral permeability and perfusion detected by dynamic contrast-enhanced magnetic resonance imaging with Patlak model in relapsing-remitting multiple sclerosis

Therapeutics and Clinical Risk Management
Hua XiongZhuoyue Tang

Abstract

To investigate the features of cerebral permeability and perfusion detected by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with Patlak model in relapsing-remitting multiple sclerosis (RRMS) and their correlations with Expanded Disability Status Scale (EDSS) scores and disease duration. Twenty-seven RRMS patients underwent conventional MRI and DCE-MRI with 3.0 T magnetic resonance scanner were enrolled in the study. A Patlak model was used to quantitatively measure MRI biomarkers, including volume transfer constant (Ktrans), fractional plasma volume (Vp), cerebral blood flow (CBF), and cerebral blood volume (CBV). The correlations of MRI biomarkers with EDSS scores and disease duration were analyzed. The MRI biomarkers Ktrans, Vp, CBF, and CBV of contrast-enhancing (CE) lesions were significantly higher (P<0.05) than those of non-enhancing (NE) lesions and normal-appearing white matter (NAWM) regions. The skewness and kurtosis of Ktrans values in CE lesions were significantly higher (P<0.05) than that of NE lesions. No significant correlation was found among the biomarkers with EDSS scores and disease duration (P>0.05). Our study demonstrated the abnormalities of permeability and perfusion characteristics in m...Continue Reading

Citations

Sep 16, 2020·Investigative Radiology·Elles P ElschotJacobus F A Jansen
Nov 13, 2020·Physics in Medicine and Biology·Xiaobing FanGregory S Karczmar
Dec 19, 2020·Open Medicine·Eleftherios KontopodisEfrosini Papadaki
Jun 18, 2021·Neoplasia : an International Journal for Oncology Research·T A ArsiwalaP R Lockman

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