The Features of Inflammation Factors Concentrations in Aqueous Humor of Polypoidal Choroidal Vasculopathy

PloS One
Jie HuLin Lu

Abstract

To investigate the cytokine concentrations in the aqueous humor of patients with refractory polypoidal choroidal vasculopathy (PCV). Three separate groups of patients were studied-refractory PCV (Group A, 41 eyes), stable PCV (Group B, 39 eyes) and senile cataract (Group C, 44 eyes). Aqueous humor samples were collected at two time points for Groups A and B-before the first intravitreal ranibizumab injection and before the last injection. Aqueous humor samples were collected prior to phacoemulsification in Group C. The cytokine concentrations of interleukin 2, 6, and 8 (IL-2, IL-6, and IL-8), tumor necrosis factor α (TNF-α), monocyte chemotactic protein 1 (MCP-1), and vascular endothelial growth factor (VEGF) were measured by cytometric bead array and flow cytometry. Before the first treatment, the MCP-1, VEGF, and TNF-α levels in Group A were significantly higher than those in Group C (P < 0.05), and the MCP-1 and VEGF levels in Group A were significantly higher than those in Group B (P < 0.05). Significantly higher MCP-1 and VEGF levels were seen in Group B compared to Group C (P < 0.05). Before the final treatment, the MCP-1, VEGF, and TNF-α concentrations in Group A were significantly higher than those in Group B (P < 0.05)...Continue Reading

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Citations

Nov 5, 2019·Acta Ophthalmologica·Jakob Ørskov SørensenTorben L Sørensen
Dec 26, 2017·Current Ophthalmology Reports·Joon-Bom KimAjay E Kuriyan
Jan 27, 2019·Investigative Ophthalmology & Visual Science·Rupesh AgrawalJohn Connolly
Dec 1, 2020·Investigative Ophthalmology & Visual Science·Yutaka KatoTetsuju Sekiryu
Feb 20, 2021·Investigative Ophthalmology & Visual Science·Areum JeongMin Sagong

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

FCAP Array
SPSS

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