The features of radiation induced lung fibrosis related with dosimetric parameters

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Young-Taek OhHae-Jin Park

Abstract

Radiation induced lung fibrosis (RILF) is a major complication after lung irradiation and is very important for long term quality of life and could result in fatal respiratory insufficiency. However, there has been little information on dosimetric parameters for radiotherapy planning in the aspect of RILF. The features of RILF related with dosimetric parameters were evaluated. Forty-eight patients with non-small cell lung carcinoma who underwent post-operative radiation therapy (PORT) without adjuvant chemotherapy were analyzed. The degree of lung fibrosis was estimated by fibrosis volume and the dosimetric parameters were calculated from the plan of 3-dimensional conformal radiotherapy. The fibrosis volume and V-dose as dosimetric parameters showed significant correlation and the correlation coefficient ranged from 0.602 to 0.683 (P<0.01). The degree of the correlation line was steeper as the dose increase and threshold dose was not found. Mean lung dose (MLD) showed strong correlation with fibrosis volume (correlation coefficient = 0.726, P<0.01). The fibrosis volume is continuously increased with V-dose as the reference dose increases. MLD is useful as a single parameter for comparing rival plans in the aspect of RILF.

References

Apr 1, 1986·International Journal of Radiation Oncology, Biology, Physics·C A PerezR Birch
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Oct 2, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B LevinsonR E Coleman
Feb 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y OheY Nishiwaki
Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·M L HernandoP A Lind
Dec 31, 2002·International Journal of Radiation Oncology, Biology, Physics·Kayoko TsujinoYoshiki Takada
Feb 8, 2003·International Journal of Radiation Oncology, Biology, Physics·Yvette SeppenwooldeRandall K Ten Haken
Jul 17, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vitali MoiseenkoJake Van Dyk
Jul 17, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tiziana RancatiGiovanni Mauro Cattaneo
Apr 28, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Line ClaudeChristian Carrie
Jun 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Ellen D YorkeC Clifton Ling
Jun 21, 2005·International Journal of Radiation Oncology, Biology, Physics·Vivek Mehta
May 2, 2006·International Journal of Radiation Oncology, Biology, Physics·Feng-Ming KongRandall K Ten Haken
Feb 12, 2008·International Journal of Radiation Oncology, Biology, Physics·Gabriela StroianJan Seuntjens
Jan 17, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Cary Dehing-OberijePhilippe Lambin
Feb 23, 2010·International Journal of Radiation Oncology, Biology, Physics·Renaud MazeronLine Claude

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Citations

Jun 4, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Katherina P FarrCai Grau
May 15, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Matthew R McCurdyThomas Guerrero
Oct 17, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Giovanna MantiniPierluigi Granone
May 4, 2017·Radiation Research·Jennifer L JudgeR Matthew Kottmann
Mar 16, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M ValliA Richetti
Sep 27, 2019·Frontiers in Oncology·Lorena GiurannoMarc A Vooijs
Jun 11, 2021·The British Journal of Radiology·Wonguen JungKyubo Kim

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