The fecal microbiota of healthy donor horses and geriatric recipients undergoing fecal microbial transplantation for the treatment of diarrhea

PloS One
Caroline A McKinneyGiovanni Widmer

Abstract

Fecal microbial transplantation (FMT), a treatment for certain gastrointestinal conditions associated with dysbiosis in people, is also empirically employed in horses with colitis. This study used microbiota high-throughput sequencing to compare the fecal microbial profile of healthy horses to that of geriatric microbial transplant recipients experiencing diarrhea and tested whether FMT restores microbiota diversity. To evaluate the effect of environment and donor characteristics on the intestinal microbiota, fecal samples were collected per rectum from 15 healthy young-adult (2-12 years) and 15 geriatric (≥20 years) horses. Additionally, FMT was performed for 3 consecutive days in 5 geriatric horses with diarrhea using feces from the same healthy donor. Fecal samples were collected from both donor and recipient prior to each FMT and from recipients 24 hours following the last FMT. The profile of the fecal bacterial microbiota was compared using 16S amplicon sequencing. In contrast to diet and farm location, age did not significantly affect the healthy equine fecal microbiota, indicating that both healthy geriatric and young-adult horses may serve as FMT donors. The fecal microbiota of horses with diarrhea was significantly mor...Continue Reading

References

Jan 9, 2003·The Veterinary Clinics of North America. Equine Practice·Mary Rose Paradis
Nov 11, 2003·Journal of Microbiological Methods·G C BakerD A Cowan
Aug 3, 2006·The Veterinary Clinics of North America. Equine Practice·Darien J Feary, Diana M Hassel
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Dec 14, 2011·Journal of Clinical Microbiology·Mary C ReaColin Hill
Jun 20, 2013·Nature Immunology·Nobuhiko KamadaGabriel Núñez
Sep 19, 2014·Journal of Veterinary Internal Medicine·A SchosterL Guardabassi
Oct 19, 2016·Biotechnology Advances·Daotong LiFang Chen
Jan 15, 2017·Gut·Giovanni CammarotaUNKNOWN European FMT Working Group
Feb 7, 2018·The Veterinary Clinics of North America. Equine Practice·Angelika Schoster
Feb 7, 2018·The Veterinary Clinics of North America. Equine Practice·Marcio Carvalho Costa, Jeffrey Scott Weese
Feb 21, 2018·Journal of Veterinary Internal Medicine·Giorgio Q PereiraMarcio C Costa
Sep 2, 2018·Applied and Environmental Microbiology·Bruno C M Oliveira, Giovanni Widmer
Dec 26, 2018·Frontiers in Microbiology·Philippa K MorrisonCaroline McG Argo
Sep 29, 2019·PLoS Neglected Tropical Diseases·Bruno César Miranda OliveiraGiovanni Widmer
Oct 19, 2019·Journal of Veterinary Emergency and Critical Care·Kate S FarrellSteven E Epstein

❮ Previous
Next ❯

Citations

Aug 19, 2020·Animals : an Open Access Journal From MDPI·Luis G ArroyoMarcio C Costa
Jan 28, 2021·Animal Microbiome·Bruno C M OliveiraGiovanni Widmer
Dec 10, 2020·Animals : an Open Access Journal From MDPI·Nicola WalsheLaura Peachey
Apr 7, 2021·The Veterinary Clinics of North America. Equine Practice·Myriam Hesta, Marcio Costa
Apr 9, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Claire Elizabeth DixonS Emmanuelle Knafo
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Michele BerlandaIlaria Patuzzi
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Mathijs J P TheelenAldert L Zomer

❮ Previous
Next ❯

Datasets Mentioned

BETA
PRJEB32490

Methods Mentioned

BETA
PCR
phylogenetic profile

Software Mentioned

GenAlEx
mothur
LEfSe
SPSS Statistics
CANOCO
unifrac
anosim
Analysis of Similarity ( ANOSIM )
OptiClust

Related Concepts

Related Feeds

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Related Papers

Vnitr̆ní lékar̆ství
Igor ŠturdíkJuraj Payer
The Keio Journal of Medicine
Katsuyoshi MatsuokaTakanori Kanai
Clinica Chimica Acta; International Journal of Clinical Chemistry
Hanna Antushevich
© 2021 Meta ULC. All rights reserved