The fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin

Archives of Virology
Tung G PhanEric L Delwart

Abstract

Viral metagenomics of feces collected from 58 Peruvian children with unexplained diarrhea revealed several small circular ssDNA genomes. Two genomes related to sequences previously reported in feces from chimpanzees and other mammals and recently named smacoviruses were characterized and then detected by PCR in 1.7 % (1/58) and 19 % (11/58) of diarrheal samples, respectively. Another three genomes from a distinct small circular ssDNA viral group provisionally called pecoviruses encoded Cap and Rep proteins with <35 % identity to those in related genomes reported in human, seal, porcine and dromedary feces. Pecovirus DNA was detected in 15.5 % (9/58), 5.9 % (3/51) and 3 % (3/100) of fecal samples from unexplained diarrhea in Peru, Nicaragua and Chile, respectively. Feces containing these ssDNA genomes also contained known human enteric viral pathogens. The cellular origins of these circular ssDNA viruses, whether human cells, ingested plants, animals or fungal foods, or residents of the gut microbiome, are currently unknown.

References

Jun 26, 2003·Nucleic Acids Research·Michael Zuker
Jun 20, 2008·Journal of Clinical Microbiology·Filemon BucardoLennart Svensson
Sep 18, 2009·The Journal of General Virology·Olga BlinkovaEric L Delwart
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xiao YuXianhong Yi
Oct 21, 2011·Journal of Medical Virology·Esmeralda VizziFerdinando Liprandi
Nov 11, 2011·The Journal of General Virology·Hye Kwon KimBong Kyun Park
Mar 17, 2012·The Journal of General Virology·Tung G PhanEric Delwart
Aug 31, 2012·Journal of Virology·Terry Fei Fan NgEric Delwart
Apr 25, 2013·Archives of Virology·Andrew K CheungMarcus E Kehrli
Jul 12, 2013·The ISME Journal·Jessica M Labonté, Curtis A Suttle
Aug 27, 2013·PloS One·Saskia L SmitsBart L Haagmans
Sep 3, 2013·Virus Research·Alyssa SikorskiArvind Varsani
Sep 12, 2013·PloS One·Tung Gia PhanEric Delwart
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Feb 25, 2014·Archives of Virology·Gábor ReuterPéter Pankovics
Apr 12, 2014·Genome Announcements·Andrew K CheungRoman M Pogranichniy
Apr 30, 2014·Transactions of the Royal Society of Tropical Medicine and Hygiene·Pablo Weilg EspejoJuana Del Valle Mendoza
May 27, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Peyman Zawar-RezaArvind Varsani
Jun 26, 2014·Emerging Infectious Diseases·Saskia L SmitsMarion P Koopmans
Jan 15, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Simona KrabergerArvind Varsani
Feb 24, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Anisha DayaramArvind Varsani
Mar 26, 2015·Virus Evolution·Santiago F Elena, Oliver G Pybus

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Citations

Apr 21, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D FocosiF Maggi
Sep 25, 2017·Genome Announcements·Eda AltanEric L Delwart
Jan 16, 2019·BMC Infectious Diseases·Kristen AiemjoyJeremy D Keenan
Oct 7, 2017·Current Medicinal Chemistry·Giulia FreerMauro Pistello
Mar 25, 2018·Archives of Virology·Arvind Varsani, Mart Krupovic
Apr 10, 2019·Scientific Reports·Paulina D AninditaHirofumi Sawa
Jun 4, 2020·Virologica Sinica·Zhibin ShiJingfei Wang
Sep 17, 2020·Nature Communications·Cormac M KinsellaLia van der Hoek
May 1, 2021·International Journal of Molecular Sciences·Valerio FulciClaudia Carissimi
Aug 28, 2021·Microorganisms·Gabriel Quintanilha-PeixotoEric Roberto Guimarães Rocha Aguiar
Sep 22, 2021·Archives of Virology·Mart Krupovic, Arvind Varsani

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