PMID: 5914696Feb 1, 1966

The feeding mechanism of avian malarial parasites

The Journal of Cell Biology
M AikawaH Sprinz

Abstract

Electron microscope studies of the erythrocytic forms, including gametocytes and asexual schizonts, of the protozoa Plasmodium fallax, P. lophurae, and P. cathemerium, have revealed a "cytostome," a specialized organelle of the pellicular membrane which is active in the ingestion of host cell cytoplasm. In material fixed in glutaraldehyde and postfixed in OsO(4), the cytostome appears in face view as a pore limited by two dense circular membranes and having an inside diameter of approximately 190 mmicro. In cross-section, the cytostome is a cavity bounded on each side by two dense segments corresponding to the two dense circles observed in face view; its base consists of a single unit membrane. In the process of feeding, the cytostome cavity enlarges by expansion of its membrane, permitting a large quantity of red cell cytoplasm to come into contact with the cytostome wall. Subsequent digestion of erythrocyte cytoplasm occurs exclusively in food vacuoles which emanate from the cytostome invagination. As digestion progresses, the food vacuoles initially stain more densely and there is a marked build-up of hemozoin granules. In the final stage of digestion, a single membrane surrounds a cluster of residual pigment particles and v...Continue Reading

References

Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·J H LUFT
Jan 13, 1962·British Medical Journal·P C GarnhamR G Bird
Jan 1, 1963·Transactions of the Royal Society of Tropical Medicine and Hygiene·P C GarnhamJ R Baker
Feb 1, 1960·The Journal of Biophysical and Biochemical Cytology·C G HuffD V JENSEN
Oct 1, 1961·Experimental Cell Research·D R PITELKA

Citations

May 2, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·D W Büttner
Jan 1, 1966·Zeitschrift für Zellforschung und mikroskopische Anatomie·C F Bardele
Jan 1, 1969·Transactions of the Royal Society of Tropical Medicine and Hygiene·E G Hartley
Nov 19, 2002·International Journal for Parasitology·D J Sullivan
Jan 1, 1978·Progress in Histochemistry and Cytochemistry·A F Morselt
Mar 21, 1998·Pharmacology & Therapeutics·P M O'NeillB K Park
Sep 28, 2000·Parasitology Today·Lawrence H BannisterGraham H Mitchell
Feb 1, 1969·Parasitology·J D Smyth
May 27, 1967·Nature·P B Macomber, H Sprinz
Feb 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·David A ElliottKeith A Joiner
Aug 1, 1966·The Journal of Cell Biology·P K HeplerH Sprinz
Jul 1, 1967·The Journal of Cell Biology·M AikawaH Sprinz
Oct 1, 1967·The Journal of Cell Biology·M Aikawa
Nov 1, 1966·Biological Reviews of the Cambridge Philosophical Society·P C Garnham
Nov 1, 1967·The Journal of protozoology·F C Colley
Nov 1, 1967·The Journal of protozoology·D M HammondB Chobotar
Feb 1, 1968·The Journal of protozoology·M A Rudzinska, W Trager
Feb 1, 1968·The Journal of protozoology·P C Bradbury, W Trager
May 1, 1968·The Journal of protozoology·B M Honigberg
May 1, 1968·The Journal of protozoology·F C Colley
Nov 1, 1968·The Journal of protozoology·P C Bradbury, W Trager
May 1, 1971·The Journal of protozoology·J M VetterlingP A Madden
Feb 1, 1973·The Journal of protozoology·C R Sterling, M Aikawa
Nov 1, 1974·The Journal of protozoology·W M Frerichs, A A Holbrook
May 1, 1976·The Journal of protozoology·S G Langreth
Oct 10, 2012·Molecular and Biochemical Parasitology·Marcel DeponteJude M Przyborski
Sep 10, 2010·Journal of Structural Biology·Eric HanssenLeann Tilley
May 19, 2010·International Journal for Parasitology·Eric HanssenLeann Tilley
Apr 13, 2010·Trends in Parasitology·Isabelle CoppensSean T Prigge
Mar 3, 2009·International Journal for Parasitology·Jean François Dubremetz, David J P Ferguson
Oct 20, 2007·Cellular Microbiology·Wynand A SmytheHeinrich C Hoppe
Jun 15, 2013·Angewandte Chemie·Faustine DubarChristophe Biot
Jun 1, 1969·Experimental Parasitology·C G Huff
Aug 1, 1979·Experimental Parasitology·K A Yamada, I W Sherman
Apr 1, 1976·Experimental Parasitology·T M Seed
Aug 1, 1974·Experimental Parasitology·C P Strome, R L Beaudoin
Feb 1, 1973·Experimental Parasitology·A F MorseltJ James
Jun 16, 2006·FEMS Microbiology Reviews·Giel G van DoorenGeoffrey I McFadden
Nov 19, 2011·FEMS Microbiology Reviews·Stefanie GraeweVolker T Heussler
May 5, 2009·Progress in Histochemistry and Cytochemistry·Wanderley de SouzaNarcisa L Cunha-e-Silva
Jan 1, 1968·Journal of Ultrastructure Research·J A Terzakis
Feb 14, 2018·Traffic·Olivia L McGovernVern B Carruthers
Jan 29, 2020·Cellular Microbiology·Timothy NesselJosh R Beck
May 6, 2020·The Journal of Biological Chemistry·Armiyaw S NasamuDaniel E Goldberg
Dec 1, 1977·Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology·D J FergusonJ C Simm
Jan 1, 1994·Parasitology Research·B A NicholsC E Pavesio
Aug 12, 2004·The Journal of Biological Chemistry·Michael KlembaDaniel E Goldberg
Jan 1, 1997·Annual Review of Microbiology·S E FrancisDaniel E Goldberg
Jan 1, 1968·Zeitschrift Für Parasitenkunde·E Scholtyseck
Jan 1, 1971·Zeitschrift Für Parasitenkunde·E ScholtyseckA Haberkorn
Jan 8, 2004·The Journal of Cell Biology·Michael KlembaDaniel E Goldberg
Sep 21, 2018·Scientific Reports·Joachim Michael Matz, Kai Matuschewski
Mar 1, 1968·Annals of Tropical Medicine and Parasitology·R D TheakstonB G Maegraith
Sep 1, 1966·Annals of Tropical Medicine and Parasitology·F E Cox, K Vickerman
Jan 29, 2021·Life·Olivia L McGovernVern B Carruthers
Apr 12, 2021·Frontiers in Cell and Developmental Biology·Natalie A CounihanTania F de Koning-Ward

Related Concepts

Malaria, Avian
Electron Microscopy
Plasmodium

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