The Feelings About genomiC Testing Results (FACToR) Questionnaire: Development and Preliminary Validation

Journal of Genetic Counseling
Meng LiDonald L Patrick

Abstract

The purpose of this study was to develop a brief instrument, the Feelings About genomiC Testing Results (FACToR), to measure the psychosocial impact of returning genomic findings to patients in research and clinical practice. To create the FACToR, we modified and augmented the Multidimensional Impact of Cancer Risk Assessment (MICRA) questionnaire based on findings from a literature review, two focus groups (N = 12), and cognitive interviews (N = 6). We evaluated data from 122 participants referred for evaluation for inherited colorectal cancer or polyposis from the New EXome Technology in (NEXT) Medicine Study, an RCT of exome sequencing versus usual care. We assessed floor and ceiling effects of each item, conducted principal component analysis to identify subscales, and evaluated each subscale's internal consistency, test-retest reliability, and construct validity. After excluding items that were ambiguous or demonstrated floor or ceiling effects, 12 items forming four distinct subscales were retained for further analysis: negative emotions, positive feelings, uncertainty, and privacy concerns. All four showed good internal consistency (0.66-0.78) and test-retest reliability (0.65-0.91). The positive feelings and the uncerta...Continue Reading

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Citations

Mar 4, 2020·Journal of Personalized Medicine·Colin Me HalversonEllen W Clayton
Jun 14, 2019·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jill O RobinsonStacy W Gray
Sep 15, 2020·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Chloe MightonYvonne Bombard
Dec 16, 2020·NPJ Genomic Medicine·Robin Z HayeemsUNKNOWN Medical Genome Initiative
Jan 5, 2021·Journal of Genetic Counseling·Bradley RolfSuman Jayadev
Feb 18, 2021·Genetic Testing and Molecular Biomarkers·Amy A LemkePeter J Hulick

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