The fetal outcomes after neoadjuvant platinum and paclitaxel chemotherapy during pregnancy: analysis of three cases and review of the literature.

Archives of Gynecology and Obstetrics
Ming WangYumei Wu

Abstract

Data on the outcomes of fetus who are exposed to neoadjuvant platinum and paclitaxel chemotherapy during pregnancy are lacking. Relevant data were abstracted from patients in our institution, PubMed, Embase and Cochrane Library databases. The primary assessment was the frequency of fetal death and congenital abnormalities. The secondary assessment was other negative fetal/infant outcomes including FGR, RDS, secondary malignant diseases and other recorded adverse events. Of the three infants in our center who exposed to platinum and paclitaxel chemotherapy during pregnancy, the physical evaluation and qualified Denver Developmental Screening Test showed normal findings at the last follow-up (19-24 months). Hearing evaluation among three children also showed normal findings. Another 34 infants (including a twins) of 21 studies in previous studies who exposed to platinum and paclitaxel chemotherapy during pregnancy were included in the final analysis. Of the 37 infants identified, 24 were exposed to cisplatin plus paclitaxel, and 13 were exposed to carboplatin plus paclitaxel. None of the 37 fetuses was abortion or dead during the pregnancy. 97.3% (36/37) infants were delivered by cesareans and the median gestational ages of deliv...Continue Reading

References

Dec 6, 2001·Gynecologic Oncology·A K SoodJ I Sorosky
Oct 16, 2004·Expert Review of Anticancer Therapy·Boaz WeiszMichael Lishner
Nov 29, 2005·Gynecologic Oncology·Gary S LeiserowitzLloyd H Smith
Jul 8, 2011·Surgical Oncology·E VoulgarisN Pavlidis
Jul 20, 2011·Cancer Chemotherapy and Pharmacology·Olivier MirAxel Le Cesne
Oct 28, 2011·Clinical Obstetrics and Gynecology·Molly BrewerCarolyn D Runowicz
Aug 21, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C TiseliusL Påhlman
Jul 9, 2014·Obstetrics and Gynecology·Eric C T GeijtemanLia van Zuylen
Apr 13, 2015·Archives of Gynecology and Obstetrics·Ahmed NazerHaim Arie Abenhaim
Sep 12, 2015·JAMA Oncology·Frédéric AmantJoris Robert Vermeesch
Sep 29, 2015·The New England Journal of Medicine·Frédéric AmantUNKNOWN International Network on Cancer, Infertility, and Pregnancy (INCIP)
Apr 17, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Natalie C SadlerAaron T Wright
Nov 3, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A Surbone, C Achtari
Jan 21, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Fabio ParazziniFedro Alessandro Peccatori
Feb 6, 2018·The Lancet Oncology·Jorine de HaanUNKNOWN International Network on Cancer and Infertility Pregnancy (INCIP)
Oct 12, 2018·Journal of Women's Health·Carrie M CottreauSengwee Toh
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F AmantI Zapardiel

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