PMID: 15250043Jul 14, 2004Paper

The fetal sheep: a unique model system for assessing the full differentiative potential of human stem cells

Yonsei Medical Journal
Graca Almeida PoradaEsmail D Zanjani

Abstract

The naturally occurring stem cell migratory patterns, the availability of expanding homing and engraftment sites, and the presence of tissue/organ-specific signals in the developing mammalian fetus provide the ideal setting for stem cells to exhibit their full biological potential. These characteristics combined with the relative immunological naivete of the early gestational age fetus that permits the engraftment and long-term persistence of allogeneic and xenogeneic donor stem cells make it possible to use the developing fetus to assess the in vivo potential of a variety of stem cells. We have taken advantage of these permissive characteristics of the fetus to develop a large animal model of human hematopoiesis in sheep that permits not only the long-term engraftment of human hematopoietic stem cell/progenitor cells and their differentiation into the full range of lymphohematopoietic elements, but also the relatively robust expression of their potential to contribute to the formation of non-hematopoietic tissues.

Citations

May 15, 2007·The American Journal of Bioethics : AJOB·Françoise Baylis, Jason Scott Robert
Jan 29, 2013·Human Immunology·F RezaeeM Dashty
Apr 27, 2010·Experimental Hematology·Graça Almeida-PoradaChristopher D Porada
Jul 18, 2006·Trends in Biotechnology·Klaus Hoeyer, Lene Koch
Apr 14, 2016·Molecular Therapy. Methods & Clinical Development·Graça Almeida-PoradaChristopher D Porada
Feb 9, 2007·Differentiation; Research in Biological Diversity·Bin ChenHui Z Sheng
Sep 1, 2015·Methods : a Companion to Methods in Enzymology·Christopher D PoradaGraça Almeida-Porada
May 16, 2017·Tissue Engineering. Part C, Methods·Iris RibitschFlorien Jenner
Aug 5, 2009·World Journal of Gastroenterology : WJG·Yan SunXi-Gu Chen
May 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jason Scott Robert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.