PMID: 9660877Jul 14, 1998Paper

The FGF receptor-1 tyrosine kinase domain regulates myogenesis but is not sufficient to stimulate proliferation

The Journal of Cell Biology
A J KudlaBradley B Olwin

Abstract

Ligand-stimulated activation of FGF receptors (FGFRs) in skeletal muscle cells represses terminal myogenic differentiation. Skeletal muscle cell lines and subsets of primary cells are dependent on FGFs to repress myogenesis and maintain growth. To understand the intracellular events that transduce these signals, MM14 skeletal muscle cells were transfected with expression vectors encoding chimeric receptors. The chimeras are comprised of the PDGF beta receptor (PDGFbetaR) extracellular domain, the FGFR-1 intracellular domain, and either the PDGFbetaR or FGFR-1 transmembrane domain. The chimeric receptors were autophosphorylated upon PDGF-BB stimulation and are capable of stimulating mitogen-activated protein kinase activity. Activation of the tyrosine kinase domain of either chimera repressed myogenesis, suggesting intracellular responses regulating skeletal muscle differentiation are transduced by activation of the FGFR-1 tyrosine kinase. Unexpectedly, we found that activation of either chimeric receptor failed to stimulate cellular proliferation. Thus, it appears that regulation of skeletal muscle differentiation by FGFs requires only activation of the FGFR tyrosine kinase. In contrast, stimulation of proliferation may require...Continue Reading

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Citations

Oct 18, 2002·Journal of Cellular Physiology·William J Rosoff, Sheridan L Swope
Oct 2, 2012·Nature·Joe V ChakkalakalAndrew S Brack
Apr 30, 2003·Nature Cell Biology·Carine BossardHervé Prats
Jul 8, 2005·Molecular Biology of the Cell·Cristina de AlvaroMargarita Lorenzo
May 9, 2002·Molecular and Cellular Biology·Maria I KontaridisAnton M Bennett
Sep 10, 2011·Skeletal Muscle·James Dr Knight, Rashmi Kothary
Jul 14, 2006·American Journal of Medical Genetics. Part a·S A BrugmannJ A Helms
Jul 18, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S KästnerZ Yablonka-Reuveni
Nov 15, 2018·Physiological Reviews·Lars LarssonMarco Sandri
Aug 15, 2001·The Journal of Biological Chemistry·M L WhitneyC E Murry
Mar 2, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bradley PawlikowskiBradley B Olwin
Sep 4, 2020·Signal Transduction and Targeted Therapy·Yangli XieLin Chen

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