The FGLamide-allatostatins influence foraging behavior in Drosophila melanogaster.

PloS One
Christine WangW G Bendena

Abstract

Allatostatins (ASTs) are multifunctional neuropeptides that generally act in an inhibitory fashion. ASTs were identified as inhibitors of juvenile hormone biosynthesis. Juvenile hormone regulates insect metamorphosis, reproduction, food intake, growth, and development. Drosophila melanogaster RNAi lines of PheGlyLeu-amide-ASTs (FGLa/ASTs) and their cognate receptor, Dar-1, were used to characterize roles these neuropeptides and their respective receptor may play in behavior and physiology. Dar-1 and FGLa/AST RNAi lines showed a significant reduction in larval foraging in the presence of food. The larval foraging defect is not observed in the absence of food. These RNAi lines have decreased for transcript levels which encodes cGMP- dependent protein kinase. A reduction in the for transcript is known to be associated with a naturally occurring allelic variation that creates a sitter phenotype in contrast to the rover phenotype which is caused by a for allele associated with increased for activity. The sitting phenotype of FGLa/AST and Dar-1 RNAi lines is similar to the phenotype of a deletion mutant of an AST/galanin-like receptor (NPR-9) in Caenorhabditis elegans. Associated with the foraging defect in C. elegans npr-9 mutants i...Continue Reading

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Citations

Jul 1, 2015·Scientific Reports·Julie L HentzeKim F Rewitz
Sep 17, 2015·PloS One·Megan E GarlapowTrudy F C Mackay
Dec 17, 2014·Insect Biochemistry and Molecular Biology·Meet Zandawala, Ian Orchard
Oct 12, 2012·Experimental Neurobiology·Wen-Hui Wu, Robin L Cooper
Jan 1, 2012·Insects·Naïla EvenAndrew B Barron
Nov 5, 2016·Annual Review of Entomology·Liliane SchoofsMatthias Boris Van Hiel

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Methods Mentioned

BETA
transgenic
Protein Assay
PCR
gene knock down

Software Mentioned

Graphpad Prism
Image J
ImageJ
BLAST

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