PMID: 11911881DOI: 10.1016/s0014-5793(01)03294-xMar 26, 2002Paper
The FHA domain
FEBS Letters
Daniel Durocher, Stephen P Jackson
Abstract
The forkhead-associated (FHA) domain is a small protein module recently shown to recognize phosphothreonine epitopes on proteins. It is present in a diverse range of proteins in eukaryotic cells, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins, and metabolic enzymes. It is also found in a number of bacterial proteins. This suggests that FHA domain-mediated phospho-dependent assembly of protein complexes is an ancient and widespread regulatory mechanism.
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