The fiber metabolite butyrate reduces gp130 by targeting TRAF5 in colorectal cancer cells

Cancer Cell International
Yin YuanLanjuan Li

Abstract

Dietary fiber is effective for colorectal cancer (CRC) treatment. Interleukin-6 (IL-6) and its adaptors are potential targets for CRC therapy. Butyrate, a metabolite of dietary fiber, is a new, highly safe type of targeted drug. In this study, Cell Counting Kit-8 cell viability and wound healing assays, western blot analysis, immunofluorescence staining, and xenograft tumor mouse models were used to evaluate the anticancer effect of butyrate and its possible mechanism in vivo and in vitro. Dietary fiber and sodium butyrate (NaB) decreased CRC burden by decreasing IL-6 receptor gp130 and blocking IL-6/JAK2/STAT3 axis activation in vitro and in vivo. Furthermore, NaB reduced the gp130 protein level by regulating its degradation rate via targeting TRAF5. The fiber metabolite butyrate inhibits CRC development by reducing gp130 via TRAF5.

References

Oct 5, 1996·Lancet·B D Dimitrov
Jan 4, 2008·Cancer Research·Sangmi KimRobert S Sandler
Oct 24, 2009·Nature Reviews. Cancer·Hua YuRichard Jove
Nov 13, 2013·Gastroenterology·Qiwen BenYaozong Yuan
Nov 15, 2013·Lancet·Hermann BrennerChristian Peter Pox
Dec 6, 2014·Cancer Discovery·Carlos Sebastián, Raul Mostoslavsky
Jan 13, 2015·Gastroenterology·Mingyang SongAndrew T Chan
Sep 12, 2015·Nature Reviews. Immunology·Nathan R WestFiona Powrie
Feb 18, 2016·Nature Immunology·Audrey LasryYinon Ben-Neriah
Apr 27, 2016·Pharmacology & Therapeutics·Sathish SivaprakasamNagendra Singh
Nov 10, 2016·Cell Metabolism·Thomas R FlintDouglas T Fearon
Nov 17, 2016·Nature Reviews. Gastroenterology & Hepatology·Stephen J D O'Keefe
Dec 3, 2016·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Hamed MirzaeiHamid Reza Mirzaei
Dec 7, 2016·Nature Reviews. Clinical Oncology·Cornelis J A PuntLouis Vermeulen
Jan 17, 2017·Journal of Cellular Physiology·Abdullah MoridikiaJafar Salimian
Mar 2, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Nov 4, 2017·JAMA Oncology·Mingyang SongAndrew T Chan
Jan 19, 2018·JAMA Oncology·Fred K TabungEdward L Giovannucci
Feb 7, 2018·Nature Reviews. Clinical Oncology·Daniel E JohnsonJennifer R Grandis
Apr 13, 2018·Nature·Sophie F RoerinkHans Clevers
Aug 31, 2018·Gastroenterology·Caitlin C MurphyRobert S Sandler
Sep 16, 2018·Gastroenterology·Christopher G HurtadoCynthia L Sears
Sep 27, 2018·Nature Reviews. Immunology·Simon A Jones, Brendan J Jenkins
Oct 9, 2018·Frontiers in Immunology·Sining ZhuPing Xie
Nov 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Hyunkyung KimSung Hee Baek
Aug 29, 2019·Nature Reviews. Gastroenterology & Hepatology·NaNa Keum, Edward Giovannucci
Oct 22, 2019·Lancet·Evelien DekkerMichael B Wallace
Nov 9, 2019·Epigenomics·Amir SavardashtakiMichael R Hamblin
Nov 25, 2019·Gastroenterology·Fay KastrinosRandall W Burt
Feb 12, 2020·Microbial Pathogenesis·Rasoul MirzaeiRasoul Yousefimashouf

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Methods Mentioned

BETA
xenograft
fluorescence-activated cell sorting
flow cytometry
transfection
PCR
FACS
co-immunoprecipitation

Software Mentioned

SPSS
GraphPad Prism
GEPIA
ImageJ

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