The Fibroblast Growth Factor signaling pathway

Wiley Interdisciplinary Reviews. Developmental Biology
D M Ornitz, Nobuyuki Itoh

Abstract

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs). Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins. Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways. Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels. Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning. FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways. Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and re...Continue Reading

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Citations

Dec 17, 2015·Genesis : the Journal of Genetics and Development·Matthew J AndersonMark Lewandoski
Jan 30, 2016·Cytokine & Growth Factor Reviews·Amaya García de VinuesaSabine Bailly
Feb 24, 2016·Seminars in Cell & Developmental Biology·Lina Korsensky, Dina Ron
Dec 27, 2015·Cytokine & Growth Factor Reviews·Javier Donate-CorreaJuan F Navarro González
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Nov 7, 2015·The Journal of Endocrinology·Christopher Price
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Oct 21, 2015·Frontiers in Endocrinology·Nobuyuki ItohMorichika Konishi
May 6, 2016·Frontiers in Cell and Developmental Biology·Nobuyuki ItohMorichika Konishi
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Oct 16, 2015·Seminars in Cell & Developmental Biology·Yasmine Tanner, Richard P Grose
Oct 26, 2016·Differentiation; Research in Biological Diversity·Manolis Roulis, Richard A Flavell
Jun 22, 2016·Placenta·Ben Ali Gannoun MarwaTouhami Mahjoub
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Oct 27, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elie El AghaSaverio Bellusci

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Methods Mentioned

BETA
PCR
nucleotide exchange
surface plasmon resonance
acetylation
myristoylation
nuclear translocation
ubiquitination

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