The fibrosis of ketamine, a noncompetitive N-methyl-d-aspartic acid receptor antagonist dose-dependent change in a ketamine-induced cystitis rat model

Drug and Chemical Toxicology
Miho SongYun Seob Song

Abstract

Ketamine abusers have greatly increased in number worldwide during recent years. The consumption of ketamine has increased, as have the number of published accounts of devastating urological sequelae. However, the mechanism of ketamine-associated urinary tract dysfunction remains unclear. This study was to evaluate the ketamine dose-dependency of ketamine-induced cystitis (KC) in a rat model. A total of 42 Sprague-Dawley rats (female, 10-week-old) were used. Each of the 7 KC rat models were induced by 1, 5, 10, 25 and 50 mg/kg ketamine intravenous injection for two weeks. For the sham group (n = 7), a phosphate-buffered saline (PBS) vehicle was used rather than ketamine hydrochloride. The cystometric parameters, histological examinations, staining for Masson's trichome, cytokeratin, toluidine blue and quantitative PCR were measured at two weeks following the intervention. The voiding interval gradually decreased depending upon the ketamine dose of 1, 5, 10, 25, or 50 mg/kg, respectively, and was decreased compared with Sham. Bladder capacity was decreased as ketamine dose increased. In particular, the increase of fibrosis and submucosal apoptosis were found according to the increase of the ketamine dose. The bladder apoptosis i...Continue Reading

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Citations

Jan 21, 2017·International Journal of Molecular Sciences·Qiang WangPeng Wu
Aug 27, 2018·Journal of Cellular Physiology·Zhengfei ShanDongfu Liu
Nov 24, 2019·Stem Cell Reviews and Reports·Jung Hyun ShinMyung-Soo Choo
Mar 24, 2017·American Journal of Physiology. Renal Physiology·Junpeng WangPeng Wu
Dec 6, 2017·International Journal of Molecular Medicine·Chi-Jung HuangYen-Chieh Wang
Mar 27, 2020·Neurourology and Urodynamics·Daniele CastellaniMarco Dellabella
Aug 6, 2021·Neurourology and Urodynamics·Saki SultanaChristian Lehmann

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