The fight-or-flight response is associated with PBMC expression profiles related to immune defence and recovery in swine

PloS One
Michael OsterKlaus Wimmers

Abstract

Defining phenotypes according to molecular features would promote the knowledge of functional traits like behaviour in both human and animal research. Beside physiological states or environmental factors, an innate predisposition of individual coping strategies was discussed, including the proactive and reactive pattern. According to backtest reactivity, animals assigned as high-resisting (proactive) and low-resisting (reactive) were immune challenged with tetanus toxoid in a time course experiment. Using the Affymetrix platform and qPCR, individual coping characteristics were reflected as gene expression signatures in porcine peripheral blood mononuclear cells (PBMC) at naïve state (day 0) and in response to the model antigen (day 14, day 28, and day 140). Further, the blood cell count was analysed at all stages. On the transcriptional level, processes acting on cell communication, vasculogenesis, and blood coagulation were highlighted in high-resisting animals at naïve state (day 0), temporarily blurred due to immune challenge (day 14) but subsequently restored and intensified (day 28). Notably, similar amounts of white and red blood cells, platelets and haematocrit between high-resisting and low-resisting samples suggest cop...Continue Reading

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Citations

May 31, 2017·Animal : an International Journal of Animal Bioscience·U GimsaM Tuchscherer
Mar 11, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael OsterKlaus Wimmers
Jun 15, 2017·Frontiers in Behavioral Neuroscience·Annika KrauseJan Langbein
Jul 14, 2018·Frontiers in Veterinary Science·Marie-Antonine FinkemeierBirger Puppe

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Datasets Mentioned

BETA
GSE55418

Methods Mentioned

BETA
blood collection
electronarcosis
PCR

Software Mentioned

Affymetrix
SAS

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