The filarial parasite Onchocerca volvulus generates the lipid mediator prostaglandin E(2)

Microbes and Infection
N W BrattigD W Büttner

Abstract

Prostaglandins exhibit regulatory effects on the vascular and immune system. Prostaglandin E(2) (PGE(2)) modulates T helper (Th) cell and effector cell functional reactivity, thereby promoting Th2 responses. We found significant expression of PGE(2) in male and female Onchocerca volvulus. Using immunohistology, PGE(2) was predominantly detected in the hypodermis of adult O. volvulus, the metabolically most active tissue of the filaria. In contrast, the muscles were PGE(2)-negative and the epithelia of intestine and uterus and male genital tract showed only weak staining. Oocytes were well labeled whereas embryos and sperms did not react. Less pronounced PGE(2) staining was observed in some dermal microfilariae. The expression of PGE(2) was found independent of antifilarial (ivermectin) as well as anti-endobacterial (doxycycline) treatment of O. volvulus-infected patients. PGE(2) was also demonstrated in extracts of adult worms by high-performance liquid chromatography-mass spectrometry. Release of PGE(2) from live or moribund filariae can affect the host s metabolism and immune response in favor of the filarial parasite.

References

Apr 1, 1992·The Journal of Clinical Investigation·L X Liu, P F Weller
Oct 1, 1991·Immunology Today·R P PhippsR L Roper
Sep 1, 1990·The Journal of Experimental Medicine·L X LiuP F Weller
Nov 1, 1990·Experimental Parasitology·L X Liu, P F Weller
Dec 1, 1985·The Journal of Infectious Diseases·D L LongworthP F Weller
Nov 28, 1980·Science·F A Kuehl, R W Egan
Feb 1, 1995·The Journal of Experimental Medicine·T C van der Pouw KraanL A Aarden
May 1, 1997·Tropical Medicine & International Health : TM & IH·E J Gutiérrez-PeñaS Müller
Feb 17, 1998·European Journal of Immunology·C E DemeureG Delespesse
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·G D BurchardR D Horstmann
Feb 28, 2002·Trends in Immunology·Sarah G HarrisRichard P Phipps
Nov 16, 2002·Critical Reviews in Immunology·Uki Yamashita, Etsushi Kuroda
May 30, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Ajoy Kumar Ghosh

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Citations

Jul 6, 2012·Clinical Microbiology Reviews·Fernando SimónJose Alberto Montoya-Alonso
Apr 15, 2014·European Journal of Pharmacology·Christina Alves Peixoto, Bruna Santos Silva
Jan 15, 2010·Current Opinion in Infectious Diseases·Michele E Murdoch
Oct 10, 2006·Clinical and Vaccine Immunology : CVI·R MorchónF Simón
Dec 5, 2015·Cephalalgia : an International Journal of Headache·Lena Hoem NordhaugMattias Linde
Aug 17, 2021·European Journal of Immunology·Oyebola O Oyesola, Elia D Tait Wojno

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