PMID: 6106669Jun 1, 1980Paper

The filling of molten and thixotropic formulations into hard gelatin capsules

The Journal of Pharmacy and Pharmacology
S E WalkerT Eaves

Abstract

Problems in the formulation and manufacture of conventional solid dose form products include the variation of fill weight and drug content, dissolution control of poorly water soluble drugs and dust generated during manufacture giving rise to cross contamination. We have examined the application of a liquid filling technique for the manufacture of hard gelatin capsules as a means of overcoming some of these. Filling materials are based on water-soluble hot melt polymers such as polyethylene glycol or water-dispersible thixotropic systems of pharmaceutical oils with thixotropic additives. A Zanasi LZ64 capsule filling machine was adapted to fill liquids using filling pump. No dust is generated during filling and 20 microgram doses of drug can be accurately filled without extensive processing. The formulations are simple and do not require specialist ingredients such as lubricants, binders, disintegrants and flow aids. The method of manufacture is reduced to a simple mixing and direct filling operation. The system may be applied to promote the dissolution of poorly water soluble drugs using solid solutions or solid dispersions. Slow release formulations are also available using suitable retard excipients.

References

Sep 1, 1971·Journal of Pharmaceutical Sciences·W L Chiou, S Riegelman

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Citations

Mar 21, 1998·Journal of Pharmaceutical and Biomedical Analysis·R J MarkovichJ Rosen
Aug 1, 1996·The Journal of Pharmacy and Pharmacology·S K DordunooM H Rubinstein
Jun 27, 2006·AAPS PharmSciTech·Paulus SeitavuopioJouko Yliruusi
Jan 20, 2007·AAPS PharmSciTech·Hamsaraj KaranthRayasa Ramachandra Murthy
Jun 5, 2003·Drug Development and Industrial Pharmacy·M A El MassikN A Daabis
Aug 26, 2010·Journal of Pharmaceutical Sciences·Rampurna Prasad Gullapalli
May 24, 2008·International Journal of Pharmaceutics·Yunzhe SunXing Tang
Nov 9, 2006·Drug Development and Industrial Pharmacy·Martin KuentzDieter Röthlisberger
Feb 18, 2017·Journal of Pharmaceutical Sciences·Rampurna P Gullapalli, Carolyn L Mazzitelli
Dec 1, 1989·Alimentary Pharmacology & Therapeutics·C D Melia, S S Davis
Feb 1, 1984·The Journal of Pharmacy and Pharmacology·C McTaggartS E Walker

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