PMID: 6973701Apr 1, 1981Paper

The filum terminale of the frog spinal cord, a nontransformed glial preparation: II. Uptake of serotonin

Neurochemical Research
T RitchieB Haber

Abstract

The uptake of 5-HT was measured in the frog filum terminale (FT), a preparation composed almost exclusively of normal glia. [3H]5-HT was taken up by the FT via a high-affinity, sodium-dependent, temperature-sensitive transport system having a Km of 0.7 microM. In addition, a variety of drugs and aromatic amines known to selectively inhibit 5-HT uptake by synaptosomes and brain slices affected the uptake of 5-HT by the FT in qualitatively similar manner. The FT was shown to accumulate [3H]5-HT at rates significantly greater than the lumbar enlargement which contains both neurons and glia. The glial accumulation of 5-HT by the FT was verified by autoradiography. These findings strongly support the suggestion that glia may modulate aminergic transmission by competing with neurons for the reuptake of neuronally released amines.

References

Jan 1, 1976·Advances in Experimental Medicine and Biology·A HambergerC T Woiler
Jan 1, 1977·Journal of Neurochemistry·V J BalcarP Mandel
Aug 24, 1979·Brain Research·R W Soller, S D Erulkar
Jun 1, 1979·Journal of Neurochemistry·J BorgP Mandel
Oct 1, 1975·Analytical Biochemistry·H T Hutchison, B Haber
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·F A Henn, A Hamberger
Jul 19, 1972·Nature: New Biology·N G Bowery, D A Brown
Jan 1, 1973·Biochemical Pharmacology·M H KannengiesserJ P Raynaud

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Citations

Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M H VilijnJ A Kessler
Jan 1, 1992·Glia·E J AndersonH K Kimelberg
Feb 6, 2020·Frontiers in Cellular Neuroscience·Yann Develle, Hugues Leblond

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