The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in The Gambia

Infection and Immunity
Patrick H CorranEleanor M Riley

Abstract

In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-1(19))-specific erythrocyte invasion inhibitory activity of antibodies to MSP-1(19) but find no significant association between any of these parameters and prevalence or density of malarial parasitemia, except that, after correcting for total anti-MSP-1(19) antibody levels, individuals with anti-MSP-1(19) antibodies that compete with an invasion inhibitory monoclonal antibody (12.10) were significantly less likely to have malaria infections with densities of > or =1,000 parasites/microl than were individuals without such antibodies. This association persisted after correction for age and ethnic origin.

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Citations

Jun 2, 2011·The Journal of Infectious Diseases·Philip BejonChris J Drakeley
Aug 6, 2011·The Pediatric Infectious Disease Journal·Matthew B McCarraChandy C John
Nov 18, 2009·Infection and Immunity·Peter D CromptonSusan K Pierce
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Jul 3, 2017·International Journal for Parasitology·Danika L HillDanny W Wilson

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