The first case of type B infant botulism in Japan

Acta Paediatrica Japonica; Overseas Edition
H KakinumaS Nakamura

Abstract

A six-month-old girl with a 5 consecutive day history of constipation and poor feeding developed generalized weakness, poor head control, difficulties in sucking and swallowing, and cranial nerve dysfunction within a few days. These characteristic manifestations and clinical course prompted examination of the possibility of infant botulism, although no history of eating honey was obtained. Mouse bioassay performed with enema effluent demonstrated type B botulinum toxin. Culture of the effluent was positive for Clostridium botulinum type B. This is the first case of type B infant botulism in Japan.

References

Feb 1, 1979·The Journal of Pediatrics·S S ArnonJ Chin
Dec 1, 1992·The Journal of Infectious Diseases·B A WoodruffC L Hatheway
Oct 1, 1990·Japanese Journal of Medical Science & Biology·H NakanoG Sakaguchi
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Feb 1, 1994·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Y MorikawaM Nukina
Nov 1, 1993·Clinical Pediatrics·J M Wigginton, P Thill

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Citations

Jun 1, 1997·Acta Paediatrica Japonica; Overseas Edition·H KakinumaH Takahashi
Jul 3, 2009·Journal of Clinical Microbiology·Kaoru UmedaShunji Kozaki
Jun 16, 2005·Journal of Clinical Microbiology·Eric A JohnsonE David G McIntosh
Dec 7, 2007·Pediatric Neurology·Yuichi AbeAkira Oka
Feb 26, 2005·Pediatric Neurology·Christine K FoxJonathan B Strober
Jan 13, 2015·International Journal of Food Microbiology·Conor J DoylePaul D Cotter
Sep 13, 2017·Microbiology and Immunology·Tomoko KohdaMasafumi Mukamoto
Aug 5, 2017·Nature Communications·Sicai ZhangPål Stenmark
May 12, 2018·Toxins·Domenico Azarnia Tehran, Marco Pirazzini
Feb 14, 2018·Toxicon : Official Journal of the International Society on Toxinology·Andrew C DoxeyCesare Montecucco

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Botulism (ASM)

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

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Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

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