The first histological and immunohistochemical examination of thymus in a case of fetus in fetu

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
Ivan VargaStefan Polak

Abstract

Fetus in fetu (FIF) is a rare condition with less than 150 cases reported in the world to the best of our knowledge. It is a malformed monozygotic twin ("non-dominant twin"), which is found inside the body of a living child or sometimes in an adult ("dominant twin"). Different organs can be seen in these fetuses; vertebral column limbs, central nervous system, gastrointestinal tract, vessels, and genitourinary tract. In the literature, we found only two cases of fetus in fetu with the present thymic tissue. In this paper, the thymus of non-dominant twin exteriorized from the mediastini of dominant twin, was analyzed by histological and imunohistochemical methods. Even though the majority of organs did not develop normally in the mentioned case, thymic tissue was proved to be present in many body parts of the non-dominant twin. In spite of the fact that the cortex and the medulla were not so distinguishable as in the normal thymuses, presence of many basic cell populations was demonstrated: thymic epithelial cells (AE1/AE3 positive cells), T (CD45RO positive) and B (CD20 positive) cells, macrophages (CD68 positive cells), dendritic cells (S100 positive cells) and myoid cells (desmin positive). The Hassall's bodies were localized...Continue Reading

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Citations

Sep 9, 2011·Surgical and Radiologic Anatomy : SRA·Vladimir CingelIvan Varga
Apr 4, 2014·BMC Pediatrics·Yi JiBo Xiang
Oct 13, 2012·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Maria BaiPanagiotis Kanavaros

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