The First Recombinant Viper Three-Finger Toxins: Inhibition of Muscle and Neuronal Nicotinic Acetylcholine Receptors

Doklady. Biochemistry and Biophysics
Ya V MakarovaYu N Utkin

Abstract

Genes encoding two three-finger toxins TFT-AF and TFT-VN, nucleotide sequences of which were earlier determined by cloning cDNA from venom glands of vipers Azemiops feae and Vipera nikolskii, respectively, were expressed for the first time in E. coli cells. The biological activity of these toxins was studied by electrophysiological techniques, calcium imaging, and radioligand analysis. It was shown for the first time that viper three-finger toxins are antagonists of nicotinic acetylcholine receptors of neuronal and muscle type.

References

Sep 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·J J SchmidtL A Smith
Apr 12, 2000·Progress in Neurobiology·D Paterson, A Nordberg
Mar 27, 2003·Toxicon : Official Journal of the International Society on Toxinology·S NirthananR M Kini
Jan 28, 2004·Journal of Pharmacological Sciences·Selvanayagam Nirthanan, Matthew C E Gwee
Oct 2, 2007·Toxicon : Official Journal of the International Society on Toxinology·Joze Pungercar, Igor Krizaj
Aug 30, 2008·Neuropharmacology·Neil S Millar, Cecilia Gotti
Jan 8, 2009·Physiological Reviews·Edson X AlbuquerqueScott W Rogers
May 23, 2012·The Journal of Biological Chemistry·Yuri N UtkinVictor I Tsetlin
Jun 28, 2016·Toxicon : Official Journal of the International Society on Toxinology·Ekaterina N LyukmanovaDmitry A Dolgikh

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