The first report of polymorphisms and genetic characteristics of the prion protein gene (PRNP) in horses

Prion
Yong-Chan Kim, Byung-Hoon Jeong

Abstract

Prion diseases have a wide host range, but prion-infected cases have never been reported in horses. Genetic polymorphisms that can directly impact the structural stability of horse prion protein have not been investigated thus far. In addition, we noticed that previous studies focusing on horse-specific amino acids and secondary structure predictions of prion protein were performed for limited parts of the protein. In this study, we found genetic polymorphisms in the horse prion protein gene (PRNP) in 201 Thoroughbred horses. The identified polymorphism was assessed to determine whether this polymorphism impedes stability of protein using PolyPhen-2, PROVEAN and PANTHER. In addition, we evaluated horse-specific amino acids in horse and mouse prion proteins using same methods. We found only one single nucleotide polymorphism (SNP) in the horse prion protein, and three annotation tools predicted that the SNP is benign. In addition, horse-specific amino acids showed different effects on horse and mouse prion proteins, respectively. Abbreviations: PRNP: prion protein gene; SNP: single nucleotide polymorphism; CJD: Creutzfeldt-Jakob disease; CWD: chronic wasting disease; TME: transmissible mink encephalopathy; FSE: feline spongiform...Continue Reading

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Citations

Jun 27, 2019·Acta Veterinaria Hungarica·Min-Ju Jeong, Byung-Hoon Jeong

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Datasets Mentioned

BETA
BAG32277.1

Methods Mentioned

BETA
PCR
transgenic
genotyping
nuclear magnetic resonance

Software Mentioned

PROVEAN
ClustalW2
SignalP
Wasabi
ClustW2
PANTHER
Finch TV
Geospiza
PolyPhen

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