The first untranslated exon of the human tenascin-C gene plays a regulatory role in gene transcription

FEBS Letters
R GherziL Zardi

Abstract

The transcription of the human tenascin-C (TN-C) gene is directed by a single promoter. Here we demonstrate, in transiently transfected cells, that two distinct regions of the untranslated 179 bp-long exon 1 play antagonistic roles in transcriptional regulation: bases from 1 to 20 strongly increase the transcription of the reporter gene CAT directed by the human TN-C gene promoter, while bases from 79 to 179 significantly reduce this activation.

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Citations

Apr 1, 1997·Critical Reviews in Oncology/hematology·G Vollmer
Jun 30, 2011·Cardiovascular Research·Jonathan GolledgeSimon Koblar
Dec 23, 1999·The Journal of Biological Chemistry·A BrewerR Patient
Nov 17, 1995·The Journal of Biological Chemistry·P BriataG Corte
Jun 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·F S Jones, P L Jones
Jan 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fui G GohKim S Midwood
May 15, 1996·Journal of Neuroscience Research·M NakicM Schachner
Oct 12, 2002·Genomics·Sujeewa D WijesuriyaWalter L Miller

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