The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity

The EMBO Journal
Michael J E KrienMatthew J O'Connell

Abstract

NIMA kinases appear to be the least functionally conserved mitotic regulators, being implicated in chromosome condensation in fungi and in spindle function in metazoans. We demonstrate here that the fission yeast NIMA homologue, Fin1p, can induce profound chromosome condensation in the absence of the condensin and topoisomerase II, indicating that Fin1p-induced condensation differs from mitotic condensation. Fin1p expression is transcriptionally and post-translationally cell cycle-regulated, with Fin1p kinase activity maximal from the metaphase-anaphase transition to G(1). Fin1p is localized to the spindle pole body and fin1Delta cells are hypersensitive to anti-microtubule drugs, synthetically lethal with a number of spindle mutants and require the spindle checkpoint for viability. Moreover, fin1Delta cells show unusual and extensive elaborations of the nuclear envelope. These data support a role for Fin1p in spindle function and nuclear envelope transactions at or after the metaphase-anaphase transition that may be generally applicable to other NIMA-family members.

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Citations

May 13, 2006·Current Genetics·Szu Shien NgChristopher J McInerny
May 14, 2003·Trends in Cell Biology·Matthew J O'ConnellTony Hunter
Dec 24, 2004·Molecular Biology of the Cell·Xu PengJianhua Liu
May 6, 2009·Molecular and Cellular Biology·Laura O'Regan, Andrew M Fry
Dec 14, 2004·Human Genomics·Daniel W NebertDavid R Nelson
Aug 31, 2007·Cell Division·Laura O'reganAndrew M Fry
Nov 8, 2012·Journal of Cell Science·Andrew M FryRichard Bayliss
Feb 27, 2007·Biochimica Et Biophysica Acta·Andreas HoubenLiudmila Vlasenko
Oct 9, 2012·Current Opinion in Cell Biology·Dan Zhang, Snezhana Oliferenko
Aug 16, 2008·International Journal for Parasitology·Marc-Jan GubbelsTomasz Szatanek
Jul 19, 2002·Yeast
Nov 5, 2013·Eukaryotic Cell·Meera GovindaraghavanStephen A Osmani
May 16, 2007·The Journal of Biological Chemistry·Ana KosoyMatthew J O'Connell
Aug 3, 2002·The Journal of Biological Chemistry·Kohji NoguchiYoshimasa Uehara
Nov 11, 2005·Journal of Cell Science·Lynne M Quarmby, Moe R Mahjoub
Dec 12, 2003·Genetics·Colin P C De SouzaStephen A Osmani

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