The Flagellum Attachment Zone: 'The Cellular Ruler' of Trypanosome Morphology

Trends in Parasitology
Jack D Sunter, Keith Gull

Abstract

A defining feature of Trypanosoma brucei cell shape is the lateral attachment of the flagellum to the cell body, mediated by the flagellum attachment zone (FAZ). The FAZ is a complex cytoskeletal structure that connects the flagellum skeleton through two membranes to the cytoskeleton. The FAZ acts as a 'cellular ruler' of morphology by regulating cell length and organelle position and is therefore critical for both cell division and life cycle differentiations. Here we provide an overview of the advances in our understanding of the composition, assembly, and function of the FAZ.

References

Jun 12, 1989·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T Sherwin, K Gull
Dec 30, 1998·Trends in Biochemical Sciences·F J Slack, G Ruvkun
Mar 6, 2002·The Journal of Biological Chemistry·Douglas J LaCountJohn E Donelson
Oct 9, 2003·The EMBO Journal·Linda KohlPhilippe Bastin
Jul 16, 2005·Science·Najib M El-SayedBjörn Andersson
Jul 16, 2005·Science·Matthew BerrimanNajib M El-Sayed
Jul 16, 2005·Science·Alasdair C IvensPeter J Myler
Oct 29, 2005·Science·Cynthia Y HeGraham Warren
Jan 5, 2006·EMBO Reports·Marc Neumann, Markus Affolter
Jan 18, 2006·Journal of Structural Biology·Gustavo Miranda RochaTecia M U Carvalho
Aug 3, 2006·Journal of Cell Science·Carole BranchePhilippe Bastin
Jul 21, 2007·The Journal of Biological Chemistry·Daniel C TurnockMichael A J Ferguson
Sep 15, 2009·Trends in Parasitology·Reuben SharmaMark Carrington
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Catarina GadelhaKeith Gull
Oct 7, 2009·Nature Reviews. Microbiology·Mark C Field, Mark Carrington
Dec 2, 2009·The Journal of Cell Biology·Raphaël DemonchyLinda Kohl
Dec 17, 2010·Cellular Microbiology·Brice RotureauPhilippe Bastin
Dec 21, 2011·The Journal of Cell Biology·Oxana E NekrasovaKathleen J Green
Mar 20, 2012·Journal of Cell Science·Kyojiro N Ikeda, Christopher L de Graffenried
Feb 26, 2013·The Journal of Biological Chemistry·Simon AllenMichael A J Ferguson
Jul 31, 2013·Trends in Cell Biology·Oxana Nekrasova, Kathleen J Green
Nov 22, 2013·PloS One·Richard John WheelerKeith Gull

❮ Previous
Next ❯

Citations

Mar 8, 2016·Cells·Doranda PerdomoDerrick R Robinson
Oct 26, 2016·Scientific Reports·Zdenka CicovaChristian J Janzen
Feb 1, 2017·PLoS Computational Biology·Richard John Wheeler
May 22, 2018·Molecular Microbiology·Nicholas A HiltonChristopher L de Graffenried
Feb 8, 2018·Parasites & Vectors·Camila Silva GonçalvesDanielle Pereira Cavalcanti
Mar 15, 2019·PLoS Neglected Tropical Diseases·Maite LoboCarlos A Buscaglia
Nov 28, 2017·Molecular Microbiology·Jenna A PerryChristopher L de Graffenried
Sep 11, 2019·Annual Review of Microbiology·Richard J WheelerJack D Sunter
Apr 3, 2020·Microbiology and Molecular Biology Reviews : MMBR·Felice D KellyScott M Landfear
Mar 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jack D SunterKeith Gull
Oct 11, 2017·Journal of Cell Science·Amy N Sinclair-DavisChristopher L de Graffenried
Oct 23, 2020·PLoS Pathogens·Clare HallidayJack D Sunter
Nov 13, 2020·Molecular Biology of the Cell·Paul C Campbell, Christopher L de Graffenried
Jul 26, 2019·Experimental Parasitology·Elisa Beatriz PrestesEdmundo Carlos Grisard
Sep 1, 2019·Trends in Parasitology·Amy N Sinclair, Christopher L de Graffenried
Oct 24, 2020·Journal of Cell Science·Ziyin WangRichard John Wheeler
Dec 15, 2020·Trends in Parasitology·Clare HallidayJack D Sunter
Aug 21, 2021·International Journal for Parasitology·María Buendía-AbadMariano Higes

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM6

Methods Mentioned

BETA
RNA-seq
dissect
scanning electron microscopy

Related Concepts

Related Feeds

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.