PMID: 11934488Apr 6, 2002Paper

The flavonoid galangin inhibits the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia

FEMS Microbiology Letters
Brian J DennyPatrick W J West

Abstract

The flavonoid galangin inhibits the partially purified metallo-beta-lactamase from Stenotrophomonas maltophilia. The effect was not reversed by the addition of ZnCl(2) suggesting that the inhibitory effect is not related to metal chelation. The flavonoid quercetin also has some inhibitory effect against the enzyme. Using the crystal structure of the enzyme, a molecular modelling study predicts a possible orientation of galangin at the active site of the enzyme.

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Citations

Apr 23, 2003·Life Sciences·Raffaele Capasso, Nicola Mascolo
Nov 3, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Griangsak EumkebSupatcharee Siriwong
Jan 24, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·T P T Cushnie, A J Lamb
May 2, 2013·Biochimica Et Biophysica Acta·Walter Fast, Larry D Sutton
Aug 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daham JeongSeunho Jung
Nov 23, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Arijit Pal, Anusri Tripathi
Jan 19, 2021·Journal of Biomolecular Structure & Dynamics·Aykut OztekinVeysel Comakli

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