The flavonoid luteolin inhibits Fcγ-dependent respiratory burst in granulocytes, but not skin blistering in a new model of pemphigoid in adult mice.

PloS One
Eva OswaldCassian Sitaru

Abstract

Bullous pemphigoid is an autoimmune blistering skin disease associated with autoantibodies against the dermal-epidermal junction. Passive transfer of antibodies against BP180/collagen (C) XVII, a major hemidesmosomal pemphigoid antigen, into neonatal mice results in dermal-epidermal separation upon applying gentle pressure to their skin, but not in spontaneous skin blistering. In addition, this neonatal mouse model precludes treatment and observation of diseased animals beyond 2-3 days. Therefore, in the present study we have developed a new disease model in mice reproducing the spontaneous blistering and the chronic course characteristic of the human condition. Adult mice were pre-immunized with rabbit IgG followed by injection of BP180/CXVII rabbit IgG. Mice pre-immunized against rabbit IgG and injected 6 times every second day with the BP180/CXVII-specific antibodies (n = 35) developed spontaneous sustained blistering of the skin, while mice pre-immunized and then treated with normal rabbit IgG (n = 5) did not. Blistering was associated with IgG and complement C3 deposits at the epidermal basement membrane and recruitment of inflammatory cells, and was partly dependent on Ly-6G-positive cells. We further used this new experi...Continue Reading

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Citations

Jan 31, 2013·Orphanet Journal of Rare Diseases·Mircea Teodor ChiriacCassian Sitaru
Mar 12, 2016·The Journal of Investigative Dermatology·Joanna JackówClaus-Werner Franzke
Jun 20, 2014·The Journal of Investigative Dermatology·Sébastien Le JanFrank Antonicelli
Apr 14, 2016·Seminars in Immunology·Tamás NémethClifford A Lowell
Oct 15, 2014·PloS One·Satoko OhfujiUNKNOWN Japanese Case-Control Study Group for Ulcerative Colitis

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Methods Mentioned

BETA
ELISA
biopsies
biopsy
light microscopy
IF
PMA
FACS

Software Mentioned

GraphPad Prism

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