The FLEP scale in diagnosing nocturnal frontal lobe epilepsy, NREM and REM parasomnias: data from a tertiary sleep and epilepsy unit

Epilepsia
Raffaele ManniAlessandra Repetto

Abstract

To test the usefulness of the FLEP scale in diagnosing nocturnal frontal lobe epilepsy (NFLE), arousal parasomnias, and REM sleep behavior disorder (RBD). The FLEP scale was applied to 71 subjects (60 male; 11 female; aged 54 +/- 21) referred to an outpatient's sleep and epilepsy unit for diagnostic assessment of nocturnal motor-behavioral episodes, which turned to be arousal parasomnias (11 subjects), NFLE (14 subjects), or idiopathic RBD (46 subjects), based on the findings of in-lab full night video polysomnography with extended EEG montages. The sensitivity of the scale as a diagnostic test for NFLE was 71.4%, the specificity 100%, the positive predictive value 100%, and the negative predictive value 91.1%. The FLEP scale gave an incorrect diagnosis in 4/71 (5.6%) of the cases, namely NFLE patients with episodes of nocturnal wandering, and uncertain diagnostic indications in 22/71 subjects (30.9%). The FLEP scale shows high positive and negative predictive values in diagnosing NFLE versus arousal parasomnias and RBD. However, the scale is associated with a real risk of misdiagnosis in some patients and gives uncertain indications in about one-third of cases, mainly RBD. Our investigation highlights the inadequacy of some of...Continue Reading

References

Jun 4, 1999·Brain : a Journal of Neurology·F ProviniP Montagna
Sep 21, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M Zucconi, L Ferini-Strambi
Sep 28, 2004·Seminars in Neurology·Carl W Bazil
Dec 7, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G PlazziP Montagna
Dec 7, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·C A TassinariS Meletti
May 10, 2006·Archives of Neurology·Christopher Paul DerrySamuel F Berkovic
Feb 14, 2007·Epilepsia·Michele TerzaghiLino Nobili

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Citations

Jan 15, 2011·Current Neurology and Neuroscience Reports·Christopher P Derry
Aug 7, 2012·Current Treatment Options in Neurology·Christopher Derry
Dec 4, 2010·Brain : a Journal of Neurology·Francesca SiclariClaudio L Bassetti
Nov 2, 2012·The Neurologist·Luigi Ferini-StrambiRomina Combi
Mar 15, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Madeleine Grigg-Damberger, Frank Ralls
Mar 15, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Aatif M Husain, Saurabh R Sinha
Nov 21, 2012·Epilepsia·Paolo TinuperFederica Provini
Jan 8, 2014·Current Neurology and Neuroscience Reports·Lino NobiliPaolo Tinuper
Jan 5, 2010·Journal of Women's Health·Cynthia L Bodkin, Carlos H Schenck
Mar 10, 2011·Current Opinion in Neurology·Sofia H Eriksson
Jul 15, 2015·Sleep Medicine Reviews·Steve A GibbsLino Nobili
Dec 16, 2011·Sleep Medicine Reviews·Ariel B Neikrug, Sonia Ancoli-Israel
Jan 31, 2012·Sleep Medicine·Alessandro PincherleFlavio Villani
Mar 29, 2011·Sleep Medicine Reviews·Esther G A van GoldeAl W de Weerd
Sep 8, 2010·Sleep Medicine·Maurice M Ohayon, Carlos H Schenck
Feb 29, 2016·Epilepsy & Behavior : E&B·Colin B JosephsonSamuel Wiebe
May 11, 2010·The Medical Clinics of North America·Eric Frenette
Jun 24, 2010·Epilepsy Research·Raffaele Manni, Michele Terzaghi
May 22, 2010·Clinics in Chest Medicine·Alon Y Avidan, Neeraj Kaplish
May 20, 2011·CNS Neuroscience & Therapeutics·Lothar BurghausNico J Diederich
Apr 8, 2010·Developmental Medicine and Child Neurology·Pasquale ParisiPaolo Curatolo
Apr 6, 2016·Neurology·Fieke M E CoxGerhard H Visser
Oct 21, 2015·Sleep Science·Shih-Bin Yeh, Carlos H Schenck
Jun 13, 2015·Der Nervenarzt·S Kotterba
Mar 8, 2013·Epilepsy & Behavior : E&B·Christopher P Derry, Susan Duncan
May 11, 2016·Neurology·Paolo TinuperRuth Ottman
Dec 29, 2016·Seizure : the Journal of the British Epilepsy Association·Paolo Tinuper, Francesca Bisulli
Jun 6, 2017·Current Opinion in Neurology·Panagiotis Bargiotas, Claudio L Bassetti
Sep 23, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L NobiliL Vignatelli
Dec 19, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Loretta GiulianoMario Zappia
Nov 9, 2019·International Journal of Environmental Research and Public Health·Victoria Garfield
Sep 21, 2010·British Journal of Hospital Medicine·Gregory Stores
Dec 11, 2020·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Jennifer MaytumJohn Belew
Apr 1, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·J Layne MooreCarl Bazil
Jun 30, 2021·Sleep Medicine Reviews·Elena AntelmiGiuseppe Plazzi
Jul 29, 2021·Journal of Pediatric Neurosciences·Ashfak H MandliVrajesh P Udani

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