PMID: 9431501Feb 12, 1998Paper

The FMR1 and FMR2 mutations are not common etiologies of academic difficulty among school-age children

Journal of Developmental and Behavioral Pediatrics : JDBP
M M MazzoccoA L Reiss

Abstract

The prevalence of the fragile X mental retardation (FMR) 1 and FMR2 full mutations (fM) was examined among 1014 school-age children with academic difficulties but without mental retardation. Both Southern blot and polymerase chain reaction analyses for FMR1 and FMR2 were performed on samples obtained from these children. No fM genes were found, and one FMR1 premutation was identified. The distribution of allele sizes for both genes was comparable to those reported for other clinical and normal population samples. These results suggest that neither the FMR1 nor the FMR2 mutation is a common etiology of academic failure among school-age children without mental retardation and that the prevalence of the FMR1 premutation is no more frequent in children with academic failure than it is in the general population.

Citations

Jun 13, 2000·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·C C TzengS J Lin
Sep 8, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·D C CrawfordS L Sherman
Dec 15, 2006·Lancet Neurology·Sebastien JacquemontMaureen A Leehey
May 29, 1998·The Journal of Pediatrics·M M MazzoccoA L Reiss
Jul 19, 2000·Mental Retardation and Developmental Disabilities Research Reviews·M M Mazzocco
Apr 22, 2006·Annals of Human Genetics·S EnnisP A Jacobs
Jan 5, 2002·Journal of Developmental and Behavioral Pediatrics : JDBP·G F MyersA L Reiss
Sep 24, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Rihui LiAllan L Reiss

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