The Food and Drug Administration's Proactive toxic anterior segment syndrome Program

Ophthalmology
Malvina B EydelmanKesia Y Alexander

Abstract

Toxic anterior segment syndrome (TASS) is a rare inflammatory condition usually observed within the first 48 hours after uncomplicated anterior segment surgery. Over the decades since its initial description, a number of TASS outbreaks have been reported. For a few of these outbreaks, the inciting factors were identified, but for the majority, the precipitating factors were often postulated but not confirmed. In light of the limitations identified in these outbreak investigations, the Food and Drug Administration's (FDA's) Center for Devices and Radiological Health staff has embarked on a number of activities aimed at mitigating medical device-related TASS outbreaks. Under the FDA-designed Proactive TASS Program (PTP), FDA scientists have conducted animal studies to better explore the inflammatory potential of suspected ophthalmic device contaminants implicated in prior cases of TASS. For contaminants displaying a TASS-like reaction in these animal models, the FDA scientists have developed analytic test methods to measure the level of those contaminants in or on ophthalmic devices. Moreover, FDA researchers have developed methods to better capture the clinical information necessary to assist investigations of potential future o...Continue Reading

References

Mar 1, 1992·Journal of Cataract and Refractive Surgery·M C MonsonR J Olson
Aug 1, 1990·Archives of Ophthalmology·R M NuytsA C Breebaart
Aug 1, 1990·Archives of Ophthalmology·A C BreebaartF D Verbraak
May 1, 1986·Journal of Cataract and Refractive Surgery·F A RichburgR J Olson
Jan 1, 1993·Journal of Ocular Pharmacology·J XiaoS Zhang
Nov 1, 1995·Ophthalmology·J C JavittA Sommer
Jan 3, 2001·Journal of Cataract and Refractive Surgery·F S JehanR J Olson
Feb 28, 2002·Archives of Ophthalmology·Chirag ParikhHenry F Edelhauser
Mar 15, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Walter C HellingerHenry F Edelhauser
Mar 28, 2006·Journal of Cataract and Refractive Surgery·Liliana WernerX Michael Liu
Mar 28, 2006·Journal of Cataract and Refractive Surgery·Nick MamalisLiliana Werner
Oct 3, 2006·Journal of Cataract and Refractive Surgery·Mustafa UnalMeryem Altin
Feb 27, 2007·Journal of Cataract and Refractive Surgery·Nick Mamalis
May 29, 2007·Journal of Cataract and Refractive Surgery·Walter C HellingerUNKNOWN ASCRS Ad Hoc Task Force on Cleaning and Sterilization of Intraocular Instruments
Mar 26, 2008·Journal of Cataract and Refractive Surgery·Preeta K KuttyArjun Srinivasan
Dec 10, 2008·Archives of Ophthalmology·Philip MaierThomas Reinhard
Dec 20, 2008·Korean Journal of Ophthalmology : KJO·Jin Seok Choi, Kyung Hwan Shyn
Sep 19, 2009·Japanese Journal of Ophthalmology·Akira SakimotoAkiko Ishimori
Feb 16, 2010·Journal of Cataract and Refractive Surgery·Eun Jung Jun, Sung Kun Chung
Nov 3, 2010·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Yusen HuangLixin Xie
Nov 30, 2010·Journal of Cataract and Refractive Surgery·Kurt BuzardMurad Sunalp

❮ Previous
Next ❯

Citations

Jul 12, 2013·The British Journal of Ophthalmology·Lingam Gopal, Lingam Vijaya
Sep 13, 2015·Cutaneous and Ocular Toxicology·Talal Abdulrahman Althomali
May 30, 2013·Ophthalmology·Michelle McMurry-Heath, Malvina Eydelman
May 30, 2013·Ophthalmology·Nick Mamalis
Oct 20, 2012·Journal of Cataract and Refractive Surgery·Nick Mamalis
Jul 4, 2012·Ophthalmology·John D Gottsch, Oliver D Schein
Apr 12, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Larissa F BaevaVictoria M Hitchins
Feb 18, 2015·Journal of Cataract and Refractive Surgery·Goichiro MiyakeAkihiko Shibuya
Apr 3, 2019·European Journal of Ophthalmology·Shmuel GraffiDan D Gaton
Jul 25, 2017·Journal of Cataract and Refractive Surgery·Artemis MatsouPeriklis Brazitikos
Dec 14, 2016·Journal of Cataract and Refractive Surgery·Andrew L SorensonDavid J Evans
Mar 4, 2020·Journal of Cataract and Refractive Surgery·Narayan BardoloiHimangshu Das
Oct 24, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Andrzej GrzybowskiUwe Pleyer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ophthalmology
John D Gottsch, Oliver D Schein
Journal of Cataract and Refractive Surgery
Carolee M Cutler PeckNick Mamalis
Investigative Ophthalmology & Visual Science
Henry F Edelhauser
© 2021 Meta ULC. All rights reserved