The footprint of metabolism in the organization of mammalian genomes.

BMC Genomics
Luisa BernáGiuseppe D'Onofrio

Abstract

At present five evolutionary hypotheses have been proposed to explain the great variability of the genomic GC content among and within genomes: the mutational bias, the biased gene conversion, the DNA breakpoints distribution, the thermal stability and the metabolic rate. Several studies carried out on bacteria and teleostean fish pointed towards the critical role played by the environment on the metabolic rate in shaping the base composition of genomes. In mammals the debate is still open, and evidences have been produced in favor of each evolutionary hypothesis. Human genes were assigned to three large functional categories (as well as to the corresponding functional classes) according to the KOG database: (i) information storage and processing, (ii) cellular processes and signaling, and (iii) metabolism. The classification was extended to the organisms so far analyzed performing a reciprocal Blastp and selecting the best reciprocal hit. The base composition was calculated for each sequence of the whole CDS dataset. The GC3 level of the above functional categories was increasing from (i) to (iii). This specific compositional pattern was found, as footprint, in all mammalian genomes, but not in frog and lizard ones. Comparativ...Continue Reading

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Citations

Mar 5, 2016·BMC Genomics·Andrea TaralloGiuseppe D'Onofrio
Dec 31, 2016·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Radka SymonováLouis Bernatchez
Mar 24, 2017·Molecular Biology and Evolution·J T DaubM Robinson-Rechavi
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Dec 8, 2015·Evolutionary Bioinformatics Online·Paolo CozziGiorgio Bernardi
Dec 10, 2017·Nature Communications·Raquel Chamorro-GarciaBruce Blumberg
Oct 21, 2016·Physiological Genomics·Andrea TaralloGiuseppe D'Onofrio

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Software Mentioned

Ensemble
Perl script Blastp
Biomart

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