PMID: 8601587Mar 1, 1996Paper

The force for poleward chromosome motion in Haemanthus cells acts along the length of the chromosome during metaphase but only at the kinetochore during anaphase

The Journal of Cell Biology
Alexey KhodjakovConly L Rieder

Abstract

The force for poleward chromosome motion during mitosis is thought to act, in all higher organisms, exclusively through the kinetochore. We have used time-lapse. video-enhanced, differential interference contrast light microscopy to determine the behavior of kinetochore-free "acentric" chromosome fragments and "monocentric" chromosomes containing one kinetochore, created at various stages of mitosis in living higher plant (Haemanthus) cells by laser microsurgery. Acentric fragments and monocentric chromosomes generated during spindle formation and metaphase both moved towards the closest spindle pole at a rate (approximately 1.0 microm/min) similar to the poleward motion of anaphase chromosomes. This poleward transport of chromosome fragments ceased near the onset of anaphase and was replaced. near midanaphase, by another force that now transported the fragments to the spindle equator at 1.5-2.0 microm/min. These fragments then remained near the spindle midzone until phragmoplast development, at which time they were again transported randomly poleward but now at approximately 3 microm/min. This behavior of acentric chromosome fragments on anastral plant spindles differs from that reported for the astral spindles of vertebrate c...Continue Reading

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Citations

Jan 1, 1997·Cell Motility and the Cytoskeleton·A KhodjakovC L Rieder
Jan 26, 2002·Cell Motility and the Cytoskeleton·James R LaFountainConly L Rieder
Mar 23, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Han Zhang, R Kelly Dawe
Jul 18, 2012·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·António J Pereira, Helder Maiato
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May 14, 2017·The Journal of Cell Biology·Travis KargWilliam Sullivan
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Jan 30, 2021·PLoS Genetics·Hannah VicarsWilliam Sullivan
Jul 27, 2006·Journal of Cell Science·Pankaj DhonuksheTheodorus W J Gadella

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