PMID: 9420660Sep 1, 1995Paper

The force-interval relationship of the left ventricle: a quantitative description in patients with ischemic heart disease

Journal of Cardiac Failure
R H RitchieJ D Horowitz

Abstract

Quantitative descriptions of the mechanical restitution curve as a description of variability in ventricular performance with coupling interval in isolated tissue preparations are widely available. In humans, however, in vivo examination of the force-interval relationship is restricted to test pulse intervals shorter than the sinus cycle length (i.e., incomplete mechanical restitution). The primary objectives in this investigation were therefore to examine this aspect of mechanical restitution in patients with ischemic heart disease and to develop a quantitative description of the phenomenon. Mechanical restitution curves were constructed in 40 patients, most of whom had well-preserved left ventricular (LV) systolic function, undergoing diagnostic cardiac catheterization for the investigation of chest pain, using a single premature test pulse interval during baseline atrial pacing. The mechanical restitution curve, the relationship between LV + dP/dtmax and test pulse interval, was fitted to a rectangular hyperbolic function. From this, the parameter c, the calculated proportional decrease in LV + dP/dtmax at 60% of the resting cycle length, was derived. The mechanical restitution curve-fitting model (involving determination of...Continue Reading

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Citations

Sep 19, 2007·Cardiovascular Engineering·Sarah E AhlbergLawrence J Mulligan
Mar 10, 2000·Journal of Cardiovascular Pharmacology·C J ZeitzJ D Horowitz

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