Abstract
Quantitative descriptions of the mechanical restitution curve as a description of variability in ventricular performance with coupling interval in isolated tissue preparations are widely available. In humans, however, in vivo examination of the force-interval relationship is restricted to test pulse intervals shorter than the sinus cycle length (i.e., incomplete mechanical restitution). The primary objectives in this investigation were therefore to examine this aspect of mechanical restitution in patients with ischemic heart disease and to develop a quantitative description of the phenomenon. Mechanical restitution curves were constructed in 40 patients, most of whom had well-preserved left ventricular (LV) systolic function, undergoing diagnostic cardiac catheterization for the investigation of chest pain, using a single premature test pulse interval during baseline atrial pacing. The mechanical restitution curve, the relationship between LV + dP/dtmax and test pulse interval, was fitted to a rectangular hyperbolic function. From this, the parameter c, the calculated proportional decrease in LV + dP/dtmax at 60% of the resting cycle length, was derived. The mechanical restitution curve-fitting model (involving determination of...Continue Reading
References
Aug 1, 1979·European Journal of Pharmacology·D D Ku, B R Lucchesi
Nov 1, 1979·Cardiovascular Research·G E BarnesV S Bishop
Jan 1, 1979·Catheterization and Cardiovascular Diagnosis·W H BarryD Phillips
Dec 1, 1976·Circulation Research·P A AndersonE A Johnson
Jan 1, 1976·The Journal of Physiology·K A Edman, M Jóhannsson
May 1, 1992·Cardiovascular Research·A J Drake-HollandM I Noble
Oct 1, 1992·Cardiovascular Research·I C CooperM M Webb-Peploe
Dec 1, 1990·Circulation Research·G L Freeman, J T Colston
Apr 1, 1990·Journal of Molecular and Cellular Cardiology·I C Cooper, C H Fry
Sep 1, 1985·Journal of Cardiovascular Pharmacology·M ArtmanR J Boucek
Jul 1, 1986·The Journal of Physiology·W G Wier, D T Yue
Feb 23, 1988·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D Meirow, Y Shimoni
May 1, 1988·Cardiovascular Research·W A Seed, J M Walker
Dec 1, 1987·Circulation·D A KassK Sagawa
Jan 1, 1987·Biophysical Journal·V J SchoutenA A Verveen
Mar 26, 1985·European Journal of Pharmacology·S P ChappellM J Lewis
Nov 1, 1970·Clinical Science·Y Mahler, S Rogel
Jun 1, 1982·Circulation·J PidgeonW A Seed
Jul 1, 1983·Journal of the American College of Cardiology·A M Katz
Dec 1, 1983·Circulation Research·M R FranzM I Noble
Jul 1, 1984·Cardiovascular Research·W CullingD J Sheridan
Jun 1, 1981·Circulation·K Sagawa
May 1, 1980·Cardiovascular Research·A Broughton, P I Korner
Oct 1, 1980·Circulation Research·J PidgeonM I Noble