The force of HER2 - A druggable target in NSCLC?

Cancer Treatment Reviews
M JebbinkE F Smit

Abstract

Since several years targeted therapy has been part of treatment in NSCLC in subsets of patients with specific genetic alterations. One of these alterations involves HER2, a member of the ERBB family of tyrosine kinase receptors. Despite that HER2 alterations in NSCLC have been studied for years, there is still no consensus about subgroup definitions. In this review HER2 alterations in NSCLC are discussed, including diagnostic challenges and treatment strategies. Three principal mechanisms of HER2 alterations can be identified: HER2 protein overexpression, HER2 gene amplification and HER2 gene mutations. There are several methods for the detection of HER2 "positivity" in NSCLC, but no gold standard has been established. Laboratory methods for assessment of HER2 positivity in NSCLC include immunohistochemistry (IHC) for protein overexpression and fluorescent in situ hybridization (FISH) and next generation sequencing (NGS) for genetic alterations. Many trials testing HER2 targeted therapy in HER2 altered NSCLC has not lead to a renewed standard of care for this group of patients. Therefore, today the (re)search on how to analyse, define and treat HER2 alterations in NSCLC continues. Still there is no consensus about HER2 subgroup...Continue Reading

Citations

Nov 22, 2020·Expert Opinion on Investigational Drugs·Alessandro RizzoGiovanni Brandi
Dec 15, 2020·Critical Reviews in Oncology/hematology·Evgeny N ImyanitovEvgeny V Levchenko
Jul 23, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Pamela Abdayem, David Planchard
Aug 7, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Shuyi CenWeidong Han
Aug 7, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Barbara MeloskyQuincy Chu
Aug 26, 2021·Pharmacogenomics and Personalized Medicine·Alice MogenetPascale Tomasini

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