The forensic medical estimation of the biological age of the corpse based on the morphological changes in the skin

Sudebno-meditsinskaia ekspertiza
Yu I PigolkinD D Zolotenkov

Abstract

The objective of the present work was the immunohistochemical evaluation of the age-related dynamics of apoptosis-associated proteins contained in the human skin epidermis. We studied the samples of skin tissues obtained during the forensic medical expertises of 100 corpses of the subjects who died in the consequence of acute blood loss in the absence of injuries or pathological changes in the skin (56 men and 44 women at the age varying from 5 to 85 years). The results of this study give evidence that the histoimmunological investigations of the skin tissues can be carried out with the use of the mmunohistochemical Ki67, bcl-2, and p53 markers for the more accurate determination of the biological age of the deceased subjects. The quantitative characteristics thus obtained serve as reliable indicators of the chronic changes in the skin and can be used as the components of the combined diagnostic procedures.

References

Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·J G EinspahrG T Bowden
Sep 20, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O Johnell, J A Kanis
Aug 13, 2010·Forensic Science International : Synergy·Christoph Meissner, Stefanie Ritz-Timme
Jan 31, 2012·European Journal of Internal Medicine·Ugur KorkmazSafinaz Ataoğlu
Apr 17, 2012·Journal of Biomedical Optics·Stefan PuschmannFrank Fischer
Apr 16, 2015·Sudebno-meditsinskaia ekspertiza·G V ZolotenkovaJu I Pigolkin
Oct 6, 2017·Sudebno-meditsinskaia ekspertiza·Yu I PigolkinA V Volkov

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