The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration

Neuroscience
K E McCarson, J E Krause

Abstract

Tachykinin peptides such as substance P and neurokinin B have been widely studied as mediators of pain transmission. The expression of neurokinin-1 and neurokinin-3 receptor messenger RNAs in the spinal cord is increased following intense nociception. The opiate ligands morphine and naltrexone alter behavioral responses to formalin-induced pain and alter evoked substance P release. This study investigated whether these opiates similarly alter the expression of substance P-, neurokinin B-, neurokinin-1 receptor- and neurokinin-3 receptor-encoding messenger RNAs in spinal systems following formalin-induced nociception. Expression levels of various messenger RNAs were quantitated using solution hybridization-nuclease protection assays. Six hours after hindpaw treatment, the levels of substance P-encoding preprotachykinin messenger RNA in the lumbar dorsal root ganglia and neurokinin B, neurokinin-1 receptor and neurokinin-3 receptor messenger RNAs in the lumbar dorsal horn were increased by approximately two-fold as compared to sham-treated controls. Pretreatment with naltrexone resulted in a further increase in the nociception-induced substance P messenger RNA expression in the dorsal root ganglia; preprotachykinin messenger RNA ...Continue Reading

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Citations

Feb 8, 2008·Archives of Pharmacal Research·Nasrin Maleki-DizajiAlireza Garjani
Dec 10, 1999·Neuropharmacology·K E McCarson, S J Enna
May 12, 1997·Journal of the Autonomic Nervous System·E K TalmageG M Mawe
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Sep 20, 2006·Journal of Neuroscience Research·Qi WanWen-Zhe Ho
Feb 8, 2011·Journal of Neuroinflammation·Lynne ShanleyAlasdair MacKenzie
Sep 23, 2016·PloS One·Clas LinnmanMagnus Peterson
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Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·J S Mogil, K E McCarson

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