The formation and functional consequences of heterogeneous mitochondrial distributions in skeletal muscle.

The Journal of Experimental Biology
B PathiB R Locke

Abstract

Diffusion plays a prominent role in governing both rates of aerobic metabolic fluxes and mitochondrial organization in muscle fibers. However, there is no mechanism to explain how the non-homogeneous mitochondrial distributions that are prevalent in skeletal muscle arise. We propose that spatially variable degradation with dependence on O(2) concentration, and spatially uniform signals for biogenesis, can account for observed distributions of mitochondria in a diversity of skeletal muscle. We used light and transmission electron microscopy and stereology to examine fiber size, capillarity and mitochondrial distribution in fish red and white muscle, fish white muscle that undergoes extreme hypertrophic growth, and four fiber types in mouse muscle. The observed distributions were compared with those generated using a coupled reaction-diffusion/cellular automata (CA) mathematical model of mitochondrial function. Reaction-diffusion analysis of metabolites such as oxygen, ATP, ADP and PCr involved in energy metabolism and mitochondrial function were considered. Coupled to the reaction-diffusion approach was a CA approach governing mitochondrial life cycles in response to the metabolic state of the fiber. The model results were consi...Continue Reading

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Citations

Apr 10, 2013·Biotechnology and Bioengineering·B PathiB R Locke
Dec 12, 2012·Cell Biochemistry and Function·Janaína KollingAngela T S Wyse
Jul 16, 2013·Nature Communications·Ana Gabriela JimenezStephen T Kinsey
Dec 13, 2016·Integrative and Comparative Biology·D Ann PabstSentiel A Rommel
Nov 6, 2020·BioMed Research International·David G LevittMichael D Levitt
Feb 9, 2013·The Journal of Experimental Biology·B P VeltenD A Pabst

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