PMID: 374891Feb 1, 1979Paper

The formation of altered enzymes in aging animals

Mechanisms of Ageing and Development
M Rothstein

Abstract

Evidence is accumulating which supports the idea that the alteration of enzymes is due to post-synthetic modifications rather than to sequence changes. Although unequivocal proof is still lacking, the idea that the changes in old enzymes are due to a subtle denaturation rather than to covalent changes is strengthened by recent work. That altered enzymes may result from a slowed protein turnover in old organisms appears to be a viable hypothesis.

References

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Citations

Jan 1, 1983·The International Journal of Biochemistry·A BartkowiakG Bartosz
Nov 1, 1979·Mechanisms of Ageing and Development·J Y Le GallA Guillouzo
Jan 1, 1980·Mechanisms of Ageing and Development·R B Burrows, P F Davison
Jan 1, 1980·Mechanisms of Ageing and Development·G Bartosz
Nov 1, 1981·Mechanisms of Ageing and Development·G BartoszW Retelewska
Sep 1, 1984·Mechanisms of Ageing and Development·N W Flodin
Sep 1, 1984·Mechanisms of Ageing and Development·H S TargovnikP V Hariharan
Aug 1, 1984·Mechanisms of Ageing and Development·A A Okada, J F Dice
Mar 1, 1987·Mechanisms of Ageing and Development·B M Stanulis-Praeger
Oct 1, 1988·Mechanisms of Ageing and Development·M Nakano, H Tauchi
Dec 1, 1988·Archives of Gerontology and Geriatrics·M Prabhakaram, S N Singh
Sep 1, 1992·Mutation Research·K S Rao, L A Loeb
Nov 24, 2001·Mechanisms of Ageing and Development·Alexey G Ryazanov, Bradley S Nefsky
Nov 24, 2001·Mechanisms of Ageing and Development·Nektarios Tavernarakis, Monica Driscoll
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H K Sharma, M Rothstein
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Jul 26, 1982·Biochimica Et Biophysica Acta·L S Hiremath, M Rothstein
Aug 7, 1980·Biochimica Et Biophysica Acta·M RothsteinH K Sharma

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