The formation of appropriate central and peripheral connexions by foreign sensory neurones of the bullfrog

The Journal of Physiology
E Frank, M Westerfield

Abstract

1. The ability of foreign sensory neurones to form novel reflex pathways was studied in bullfrogs by removing, during early larval stages of development, the dorsal root ganglion (d.r.g. 2) that normally provides the entire sensory innervation of the front limb.2. After the operation these tadpoles metamorphosed into frogs that responded to sensory stimuli and had nearly normal use of the limb. Sensation in the limb was mediated by sensory neurones located in an adjacent ganglion (d.r.g. 3); these neurones normally never grow into the arm.3. These neurones were shown, by labelling with horseradish peroxidase, to project into the arm and into the region of the brachial spinal cord occupied by motoneurones innervating muscles in the arm. These projections do not occur at any time during normal development.4. Intracellular recordings from identified motoneurones demonstrated that when the operations were done before developmental stage 9 appropriate monosynaptic sensory-motor pathways were established. The relative strengths of synergistic and antagonistic sensory projections onto motoneurones were normal, although the latencies of the synaptic potentials were somewhat longer.5. When the operation was performed after stage 9 but b...Continue Reading

Citations

Oct 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S C Mears, E Frank
Sep 1, 1984·The Journal of Comparative Neurology·T J Ruigrok, A Crowe
Sep 13, 2001·The European Journal of Neuroscience·A M RitterH R Koerber
Oct 1, 1992·Journal of Neurobiology·C S von BartheldE W Rubel
Dec 20, 1983·The Journal of Comparative Neurology·M R Davis, M Constantine-Paton
Mar 1, 1988·The Journal of Comparative Neurology·C L Smith, E Frank
Jan 22, 1989·The Journal of Comparative Neurology·B M DavisS A Scott
Oct 15, 1990·The Journal of Comparative Neurology·B Mendelson, E Frank
Sep 11, 2002·Developmental Biology·Robert A Oakley, Beverly A Karpinski
Feb 1, 1989·Developmental Biology·J M SohaD C Van Essen

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