The formation of catechol isoquinolines in PC12 cells exposed to manganese

Neuroscience Letters
Yulin DengJian Zhou

Abstract

Chronic exposure to manganese causes parkinsonian symptoms and has been implicated as an environmental factor in the pathogenesis of Parkinson's disease (PD). Here we show that manganese inhibits the proliferation of PC12 cells and induces apoptosis through the formation of catechol isoquinolines. Manganese induces the production of 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol, Sal) and N-methyl-salsolinol (NMSal) in PC12 cells, and increases the levels of malondialdehyde (MDA) in a dose-dependent manner. The data indicates that the formation of catechol isoquinolines due to oxidative stress induced by MnCl(2) may be a mechanism by which manganese causes degeneration of dopaminergic neurons.

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Citations

Mar 10, 2015·Biochemical and Biophysical Research Communications·Bingjie XieYulin Deng
Apr 1, 2018·ACS Chemical Neuroscience·Xuechai ChenYulin Deng
Sep 4, 2020·CNS & Neurological Disorders Drug Targets·Shee Man VoonRhun Yian Koh

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis