PMID: 6161387Jan 1, 1980Paper

The formation of tigroid substance during postnatal maturation of the brain of mice after pre- and perinatal X-irradiation

Radiation and Environmental Biophysics
G Konermann, I Schwald

Abstract

Using Nissl stained slices of postnatal brain, tigroid formation in neurons of the cortex, thalamus, cerebellum, hippocampus, gyrus dentatus and nucleus mot. trigemini was examined in X-irradiated mice. Following exposure on days 13, 16, 18.5 or 22 post conception with doses ranging from 0.5 Gy to 3.0 Gy tigroid formation was studied by means of a selective microphotometrical measurement technique. After irradiation, a fluctuating diminution in the tigroid density was observed in relation to the controls. It was dependent both on the dose and on the stage of development during exposure. In several brain regions fluctuating tigroid responses, being most pronounced during the "critical periods" of postnatal brain maturation, resulted in a longterm compensation of a deficit in the tigroid density after irradiation with 0.05 Gy. After the higher doses the density diminution was either not compensated or was progressive. The late tigroid responses decrease from irradiation on day 13 p.c. to irradiation day 22 p.c. Hence, this type of late maturation impairment was either extended through several cell generations or it was induced to a lesser degree in the early postmitotic neurons. Changes in the total RNA-content of the brain are c...Continue Reading

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Citations

Oct 9, 1999·Epilepsy Research·K M JacobsD A Prince
Dec 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R P JenshW H Vogel
Aug 1, 1992·International Journal of Radiation Biology·Z J SienkiewiczB K Butland
Feb 1, 1995·International Journal of Radiation Biology·R P JenshR L Brent
Oct 9, 2003·Annals of the ICRP·Roger Cox, Christian Streffer

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