The fortification method relying on assumed human milk composition overestimates the actual energy and macronutrient intakes in very preterm infants

Maternal Health, Neonatology and Perinatology
Israel MacedoManuela Cardoso

Abstract

To achieve recommended nutrient intakes in preterm infants, the target fortification method of human milk (HM) was proposed as an alternative to standard fortification method. We aimed to compare assumed energy and macronutrient intakes based on standard fortified HM with actual intakes relying on measured composition of human milk (HM), in a cohort of HM-fed very preterm infants. This study is a secondary retrospective analysis, in which assumed energy and macronutrient contents of daily pools of own mother's milk (OMM) from 33 mothers and donated HM (DHM) delivered to infants were compared with the measured values using a mid-infrared HM analyzer. A fortification method consisting of modular protein and/or fat supplements added to standard fortified HM was used to provide the minimum recommended daily intakes of energy 110 Kcal/kg and protein up to 4.0 g/kg. Assumed nutrient intakes were compared with actual nutrient intakes from full enteral feeding to 35 weeks plus 6 days postmenstrual age, using the Wilcoxon matched-pairs signed ranks test. The composition of 1181 samples of daily pools of HM were measured. For 90.2% of study days, infants were exclusively fed OMM and in remaining days fed OMM plus DHM. Comparing with repo...Continue Reading

References

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Feb 6, 2017·Clinics in Perinatology·Francis B MimouniDror Mandel

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Citations

Oct 18, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Anish PillaiRajavel Elango
Jan 23, 2021·International Journal of Environmental Research and Public Health·Manuela CardosoLuís Pereira-da-Silva
Apr 21, 2021·American Journal of Perinatology·Lia CorreiaLuís Pereira-da-Silva
Jul 3, 2021·International Journal of Environmental Research and Public Health·Gustavo RochaLuís Pereira-da-Silva

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