The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect.

Oncogene
Qingguo LiDawei Li

Abstract

Aberrant expression of Forkhead box (FOX) transcription factors plays vital roles in carcinogenesis. However, the function of the FOX family member FOXC1 in maintenance of colorectal cancer (CRC) malignancy is unknown. Herein, FOXC1 expression in CRC specimens in The Cancer Genome Atlas (TCGA) cohort was analyzed and validated using immunohistochemistry with a tissue microarray. The effect of FOXC1 expression on proliferation of and glycolysis in CRC cells was assessed by altering its expression in vitro and in vivo. Mechanistic investigation was carried out using cell and molecular biological approaches. Our results showed that FOXC1 expression was higher in CRC specimens than in adjacent benign tissue specimens. Univariate survival analyses of the patients from whom the study specimens were obtained, and validated cohorts indicated that ectopic FOXC1 expression was significantly correlated with shortened survival. Silencing FOXC1 expression in CRC cells inhibited their proliferation and colony formation and decreased their glucose consumption and lactate production. In contrast, FOXC1 overexpression had the opposite effect. Furthermore, increased expression of FOXC1 downregulated that of a key glycolytic enzyme, fructose-1,6-...Continue Reading

References

Feb 24, 1956·Science·O WARBURG
Oct 15, 2005·Clinical Radiology·K WechalekarG Cook
Oct 19, 2007·Nature Reviews. Cancer·Stephen S Myatt, Eric W-F Lam
Sep 25, 2008·Ernst Schering Foundation Symposium Proceedings·C V Dang
Jan 15, 2009·Nature Reviews. Cancer·Nicholas C Denko
Mar 11, 2009·Nature Reviews. Genetics·Sridhar Hannenhalli, Klaus H Kaestner
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Feb 11, 2010·Cancer Research·Hiroyasu KanedaKazuto Nishio
Nov 18, 2010·Carcinogenesis·William K K WuJoseph J Y Sung
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dawei LiKeping Xie
Jun 6, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Efsevia VakianiDavid B Solit
Aug 23, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Limin XiaKaichun Wu
Nov 9, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dawei LiKeping Xie
Nov 30, 2012·Cancer Biology & Therapy·Yi Zhang, Jin-Ming Yang
Dec 18, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lei WangJun-Ying Xu
Dec 25, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Long-Xiao WeiMeng-Hui Yuan
Feb 1, 2013·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Arif O KhanFowzan S Alkuraya
Mar 19, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jiujie CuiKeping Xie
Jun 21, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Min ShiKeping Xie
Jul 22, 2014·Nature·Bo LiM Celeste Simon
Jul 22, 2014·Genes, Chromosomes & Cancer·Stefan NagelRoderick A F MacLeod
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 19, 2015·Molecular Biology Reports·Rupert CourtnayTom C Karagiannis
Jun 5, 2015·Journal of the National Cancer Institute·Tor W JensenPartha S Ray
Aug 25, 2015·Gastroenterology·Rajagopal N Aravalli, Tim F Greten
Nov 3, 2016·Nature Reviews. Clinical Oncology·Ubaldo E Martinez-OutschoornMichael P Lisanti
May 11, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wenhao WengAjay Goel
Jul 13, 2016·Molecular Cancer Research : MCR·Qingguo LiSanjun Cai
Jul 28, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kun GuoKeping Xie

❮ Previous
Next ❯

Citations

Feb 16, 2019·Cancers·L Niall Gilding, Tim C P Somervaille
May 23, 2019·Cancer Cell International·Yanzhu LinXinping Cao
Oct 28, 2019·The Journal of Pathology·Yi ZhangHonghe Zhang
Dec 1, 2019·Journal of Experimental & Clinical Cancer Research : CR·Xiaoming BaiJinshun Pan
Jan 11, 2020·Cell Communication and Signaling : CCS·Weixing DaiGuoxiang Cai
Sep 17, 2020·Molecular and Cellular Biochemistry·Jun Qiu, Bei Yang
Mar 7, 2021·International Journal of Molecular Sciences·Hongni XueZekun Guo
Jun 25, 2021·Asia-Pacific Journal of Clinical Oncology·Wu NingWenyue Wang
Sep 18, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jun LuChang-Ming Huang
Sep 29, 2020·The International Journal of Biochemistry & Cell Biology·Bin ZhangKun Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging technique
flow cytometry
xenograft
Assay
immunoprecipitation
transfection
PCR

Software Mentioned

SPSS
CXP

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.