The fractional distribution of the cardiac output in man using microspheres labelled with technetium 99m

The British Journal of Radiology
P A CreanA Maseri

Abstract

To investigate the distribution of organ blood flow in patients we have developed a method of quantitating the whole-body fractional distribution of 99Tcm-labelled microspheres. The microspheres were injected into the left ventricle in nine patients with normal cardiac indices (greater than 3 1/min/m2; Group A) and 11 patients with low cardiac indices (less than 2.51 l/min/m2; Group B). The fractional organ content of the total injected dose was estimated following correction for geometry and transmission using a gamma camera. Cerebral blood flow was 579 +/- 163 ml/min (mean +/- SD) in Group A and 593 +/- 158 ml/min in Group B (p not significant (NS)). Myocardial flow in Group A was 266 +/- 82 ml/min and in Group B was 237 +/- 57 ml/min (p, NS). Total renal blood flow was 749 +/- 161 ml/min in Group A and 614 +/- 181 ml/min in Group B (p less than 0.01). There was a negative correlation between cardiac index and the percentage of the cardiac output distributed to brain (r = -0.70, p less than 0.01), heart (r = -0.67, p less than 0.01) and kidneys (r = -0.47), p less than 0.05). Low output cardiac failure is, therefore, associated with relative preservation of cerebral and myocardial blood flow and, to a lesser extent, of renal ...Continue Reading

References

Jun 1, 1978·Circulation Research·A P SelwynP Lavender
Oct 1, 1971·Journal of Applied Physiology·G D BuckbergD E Fixler
Dec 1, 1981·The British Journal of Radiology·M J MyersA Maseri
Dec 1, 1980·British Journal of Haematology·A M PetersS M Lewis
Feb 1, 1950·The American Journal of Medicine·P SCHEINBERG
Jan 1, 1948·The Journal of Clinical Investigation·R MokotoffL Leiter

Citations

Mar 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M M FitzpatrickI Gordon
Jan 2, 2009·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Chad M ThompsonKannan Krishnan
Sep 1, 1996·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·S C ReimoldR T Lee
Jun 13, 2017·International Journal of Molecular Sciences·Mauro CataldiDomenico Capone
Nov 1, 1994·Physiological Measurement·P F Sharp
Aug 1, 1989·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·L R Williams, R W Leggett
Jan 28, 2021·AIDS Research and Human Retroviruses·Aaron S Devanathan, Angela D M Kashuba

Related Concepts

Brain
Cardiac Output
Sinus Node Artery
Heart
Kidney
Latex Spheres
Regional Blood Flow
Spleen
Technetium 99m

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